The Chinese University of Hong Kong

Xin Shu

Rishikesh Pandey

Renjie Zhou

The subject invention pertains to methods and systems for classifying leukocytes using artificial intelligence called AIRFIHA (artificial-intelligence enabled reagent-free imaging hematology analyzer) that can accurately classify subpopulations of leukocytes in a label-free manner. AIRFIHA can not only subtype lymphocytes into B and T cell but is capable of sorting different types of T cells subtypes. AIRFIHA is realized through training a two-step neural network using label-free images of separated leukocytes acquired from a custom-built quantitative phase microscope. Owing to its easy operation, low cost, and strong discerning capability of complex leukocyte subpopulations, AIRFIHA is clinically translatable and can also be deployed in resource-limited settings.

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Hong Kong, China

Xin Shu