Fujian South Pharmaceutical Co., Ltd.

Shanghai Parling Pharma-Tech. Co., Ltd.

Shanghai Micro Electronics Equipment (Group) Co., Ltd.

Xin Shen

Jidong Yang

Huaxing Zhan

Xiao He

Shaohong Wu

Dan Dan Wang

Zhihong Jiang

Jianping Luo

Fuxing Lin

Hongsheng Zhang

Min Du

Pengfei Miao

Dan Wang

An interferometer measuring device is disclosed which includes a workpiece stage (), a laser interferometer () and a measuring reflector () mounted on the workpiece stage. The measuring reflector () is comprised of a plurality of planar mirrors () that are joined together along a horizontal direction. The laser interferometer () includes a first interferometer () and a second interferometer (). The first interferometer () and the second interferometer () are configured such that during a horizontal movement of the workpiece stage () with respect to the laser interferometer (), when light beams emanated from the first interferometer () and the second interferometer () are incident on a transition section () defined by corresponding adjacent two of the planar mirrors (), the light beam emanated from the first interferometer () is incident on one of the adjacent two planar mirrors () and the light beam emanated from the second interferometer () is incident on the other of the adjacent two planar mirrors (). Additionally, the first interferometer () and the second interferometer () alternately provide positional information to the workpiece stage (). A method for controlling such an interferometer measuring device is also disclosed. The interferometer measuring device and the method enable an extended horizontal measurement range for the workpiece stage () by using the plurality of planar mirrors () that are joined together as well as by alternating zero-reference updating of the two interferometers ().

Interferometer measurement device and control method therefor

A saponin nano micelle, preparing method, application and pharmaceutical composition thereof is disclosed in the present invention. The saponin nano micelle comprises one or more of saponins represented by formula 1, in which, Rand Rare independently &#x2014;H or a hydrophilic group, Ris &#x2014;H or &#x2014;OH, Ris a lipophilic group. The preparing method of the saponin nano micelle is that mixing the saponin with an organic solvent which can dissolve saponin, and then removing the organic solvent. The saponin micelle acts as a convey medium of the drug ingredients, and can replace conventional drug carriers such as pharmaceutical solubilizers or polymeric micelle, which has high safety and great significance. The pharmaceutical ingredients can prolong circulation time and biological half-life of drug in the blood, and increase the accumulation of drug in lesions, and reduce adverse reactions. 

Saponin nano micelle, preparing method, application and pharmaceutical composition thereof

Described is a process for preparing docetaxel 1, including the following steps: a) hydroxyl acylation reaction of compound 2 and 3 to obtain compound 4; b) deprotection group Rof the hydroxyl group of compound 4 obtained from step a to prepare compound 5; c) removing one tert-butoxycarbonyl of compound 5 obtained from step b to prepare compound 6; d) removing one acetyl of compound 6 obtained from step c to prepare compound 1; wherein, Rrepresents tert-butyl dimethyl silyl, triethylsilyl, ethoxyethyl, tetrahydropyranyl, trichloroethoxycarbonyl or methoxymethyl, Boc is tert-butoxycarbonyl, Ac is acetyl, and Ph is phenyl. Also disclosed are intermediates of docetaxel and methods for preparation thereof.

Process for the preparation of docetaxel, its intermediates, and methods for preparation thereof

In the present invention, a synthesis method of Imatinib is disclosed, which comprises the following steps: the Imatinib, namely 4-(4-methyl-piperazin-1-ylmethyl)-N-[4-methyl-3-[4-(3-pyridinyl)-pyrimidin-2-ylamino]-benzami de shown in formula (III), is formed by reacting 4-methyl-N-3-(4-pyridin-3-yl-pyrimidin-2-yl)-1,3-benzenediamine shown in formula (I) with 4-(4-methyl-piperazin-1-methyl)-benzoic ester shown in formula (II), under the action of a base and in a non-protonic organic solvent, in the above generic chemical structural formula, R represents aliphatic alkyl having 1-10 carbon, phenyl, substituted phenyl, benzyl or substituted benzyl. The present invention provides a new synthesis method of Imatinib, which is formed under mild reaction conditions, and is environmentally friendly with a high-yield.

Method for synthesizing Imatinib

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Shanghai, China

Xin Shen