University of North Carolina at Chapel Hill

Southern Research Institute

Xin Ming

Rudolph L Juliano

Joseph A Maddry

Bing Yang

William Perry Janzen

Lindsey James

Ling Wang

Canhong Cao

Ranathunga Arachchillage Yamuna Kumari Ariyarathna

Silvia M Kreda

This disclosure is directed to methods, compounds and compositions for delivering nucleic acids to a cell of interest. In particular, it provides salts that are particularly effective in delivering nucleic acids to cells in the lung for disorders such as cystic fibrosis (CF).

Benzimidazoles that enhance the activity of oligonucleotides

Methods of administering an oligonucleotide of interest into a cell in vitro or in vivo are described. In the methods, a small organic compound active agent is concurrently administered to the cell in an amount effective to increase the delivery of the oligonucleotide into the cell, and/or increase the activity of said oligonucleotide in the cell. Compositions useful for carrying out the method are also described.

Small molecules that enhance the activity of oligonucleotides

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Chapel Hill, NC, United States of America

Xin Ming