Ludwig Institute for Cancer Research Limited

Genome Research Limited

Ucl Cruciform Limited

Chancellors, Masters & Scholars of the University of Oxford

Xin Lu

David Lawrence Selwood

Patricia Kuwabara

Shan Zhong

Felix Zhou

Jens Rittscher

Min Lu

Elizabeth Slee

Carlos Ruiz-puig

A method for characterising motion of one or more objects in a time ordered image dataset comprising a plurality of time ordered data frames, the method comprising: selecting a reference data frame from the plurality of time ordered data frames (); extracting a plurality of image patches from at least a part of the reference data frame (); identifying a location of each image patch of at least a subset of the plurality of image patches in each data frame (); defining, based on the identified locations, a mesh for each data frame, wherein vertices of each mesh correspond to respective identified locations of image patches in the corresponding data frame (); and deriving, from the meshes, a motion signature for the time ordered image dataset, the motion signature characteristic of the motion of the one or more objects in the plurality of time ordered data frames ().

Methods and systems for analyzing time ordered image data

Described herein are methods of evaluating metastatic potential of a cancer based on the phosphorylation state and/or intracellular localization of iASPP. Therapeutic regimens designed based on the results of the diagnostic methods are also provided.

iASPP phosphorylation and metastatic potential

The invention relates to a polypeptide or part thereof which inhibits the apoptotic activity of the tumor suppressor protein p53, and includes screening methods to identify agents which interfere with the activity of the polypeptide.

Peptide inhibitors of IASPP

We describe a polypeptide which binds and modulates the activity of a tumour suppressor polypeptide, for example p53; a nucleic acid molecule encoding said protein and screening methods which modulate the binding activity of said polypeptide for its target polypeptide(s).

Tumour suppressor protein

The invention relates to polypeptides that bind to the oncogene product mdm2 and the uses of the identified polypeptides in therapeutic compositions to treat aberrant cell division in humans.

Growing community of inventors

London, United Kingdom

Xin Lu