Mayo Foundation for Medical Education and Research

Xin Liu

Cynthia H McCollough

Lifeng Yu

Eugene D Kwon

Haidong Dong

Christopher J Krco

Susan M Harrington

Materials and methods for treating cancer, including materials and methods for treating cancer in patients identified as having elevated levels of Bim.

Methods for treating cancer in patients with elevated levels of Bim

Materials and methods for treating cancer especially in patients identified as having elevated levels of Bim are disclosed. Specifically, the disclosure provides a method for treating a mammal having cancer, the method comprises: (a) identifying said mammal as containing an elevated level of Bim, and (b) administering to said mammal an anti-B7-H1 antibody, an anti-PD-1 antibody, an anti-CD80 antibody, or a fusion protein comprising a portion of PD1 or a portion of CD80, under conditions wherein the interaction of naturally occurring B7-H1 with PD-1 or CD80 in said mammal is reduced after said administering.

Methods for treating cancer in patients with elevated levels of BIM

A system and method for decomposing more than two materials in an imaging object includes performing a CT imaging acquisition of a portion of an imaging object using at least two energy levels to acquire imaging data associated with each of the at least two energy levels. A total mass attenuation of the imaging data is expressed as a weighted sum of constituent element mass attenuation coefficients and an effective atomic number and density of the constituent elements in the portion of the imaging object is determined by one of a number of methods. Accordingly, concentration of the constituent elements in imaged object is determined by solve the expression using known material attenuation coefficients and the measured CT data.

System and method for quantitative imaging of chemical composition to decompose more than two materials

The present invention provides a material decomposition method capable of determining the distribution of density and constituent material concentration throughout an imaged object. The concentration, in the form of a mass fraction, mass percent, weight fraction, or weight percent, is determined from CT images acquired at different energy levels. The ratio of attenuation coefficients associated with one energy level to attenuation coefficients associated with another energy level is determined and used as an index in a lookup table to determine the concentration of a given material throughout the imaged object.

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Rochester, MN, United States of America

Xin Liu