Bristol-Myers Squibb Compnay

Xin Huang

Wen-Pin Yang

Yuli Wu

Todd G Kirchgessner

Bonnie Hsiang

Yingjie Zhu

Jean S Lynch

Zhaoqing Wang

Edwin A Clark

Shirin K Ford

Zhaoging Wang

EGFR biomarkers useful in a method for predicting the likelihood that a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises (a) measuring in the mammal the level of at least one biomarker selected from epiregulin and amphiregulin, (b) exposing a biological sample from the mammal to the EGFR modulator, and (c) following the exposing of step (b), measuring in the biological sample the level of the at least one biomarker, wherein an increase in the level of the at least one biomarker measured in step (c) compared to the level of the at least one biomarker measured in step (a) indicates an increased likelihood that the mammal will respond therapeutically to the method of treating cancer.

Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators

The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins ('OATPs'). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the vectors and polypeptides having all or part of an OATP. Also encompasses are uses for OATPs for targeting drugs to specific organs and for modulating the concentration of endogenous substrates.

Organic anion transport proteins

The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins (&ldquo;OATPs&rdquo;). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the vectors and polypeptides having all or part of an OATP. Also encompasses are uses for OATPs for targeting drugs to specific organs and for modulating the concentration of endogenous substrates.

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Princeton, NJ, United States of America

Xin Huang