Microsoft Technology Licensing, LLC

Institute of Biotechnology, Academy of Military Medical Sciences, China

Xin Gong

Bo Liu

Li Zhu

Peng Sun

Jun Wu

Chao Pan

Hengliang Wang

Erling Feng

Shaohong Chang

Bin Wang

Eric Norman Badger

Stephen Harry Wright

Elliot H Omiya

Fang Zhang

Drew Elliott Linerud

Albert Peter Hwang

Chiwei Che

Scott Robert Honji

Harley Michael Rosnow

Ming Zeng

Daniel Chang

Sameer Garde

Tiantian Wang

Zhehui Peng

The invention provided a method for preparing a bacterial polysaccharide-modified recombinant fusion protein and use of the bacterial polysaccharide-modified recombinant fusion protein. The method comprises: co-expressing a recombinant fusion protein and theO-oligosaccharyltransferase PglL in an O-antigen ligase gene-defective bacterium, and linking a polysaccharides endogenous or exogenous for the bacterium to the recombinant fusion protein by the O-oligosaccharyltransferase PglL, to obtain the bacterial polysaccharide-modified recombinant fusion protein. The protein can be used for preparing antibodies against bacterial polysaccharides and vaccines.

Method for preparing bacterial polysaccharide-modified recombinant fusion protein and use of the protein

The present invention discloses aA with an O-antigen having an extended carbohydrate chain and uses thereof. The method comprises the following steps: inactivating an cld gene encoding an enzyme controlling chain length of O-antigen of aA strain to obtain aA with deletion of cld gene; allowing overexpression of cldgene encoding an enzyme controlling chain length of O-antigen ofinA deficient in the cld gene encoding an enzyme controlling chain length of O-antigen, so as to extend carbohydrate chain length of O-antigen. Both of theA O-polysaccharide-recombinant fusion protein conjugate vaccines rCTB4573-OPSand rEPA4573-OPSas prepared by usingA with an O-antigen having an extended carbohydrate chain can induce mice to generate specific antibodies againstA, and their antibody titers are significantly improved.

with an O-antigen having an extended carbohydrate chain and use thereof

A computer system supports a protocol to process directional navigation inputs to a host application and its component, to manage which component is currently active to receive input events. A first component determines whether to transfer focus to a second component. The first component initiates the transfer by sending a request to the second component. Further input events are queued. The second component processes the request to determine how to transfer focus within the second component. The second component indicates to the operating system how focus has been transferred. The operating system updates information to reflect the changes in state of the components, and informs the host and component that the state has been updated. Queued input events then can be released for processing according to the changed focus. Where the components are separate, independent processes, the protocol can be implemented through inter-process communication techniques.

Processing non-spatial input by multiple program elements of a computer program executed on a computer

A facility for processing textual input generated with a user input device described. In one example facility, the facility stores the textual input in a first data structure contained in the address space of a first process. The facility synchronizes contents of the first data structure to a second data structure contained in the address space of a second process distinct from the first process, an application executing in the second process being configured to consume textual input synchronized to the second data structure.

Externalized execution of input method editor

Methods, systems, and computer-storage media having computer-usable instructions embodied thereon, for displaying and inputting symbols are provided. Bopomofo symbols are phonetic representations of Chinese characters. To accommodate all the Bopomofo symbols on a mobile device keyboard without sacrificing key size, the Bopomofo keys are dynamically disabled based on grammar rules and user inputs. For example, a symbol that is not eligible to follow an input symbol is disabled such that it does not distract a user searching for a symbol in the keyboard. Further, specific keys on a keyboard are dynamically replaced with tone keys once a user inputs a symbol. A user interface for displaying the symbols is, thus, consistent and easy to navigate for a user.

Displaying and inputting symbols

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Beijing, China

Xin Gong