International Business Machines Corporation

Agency for Science, Technology and Research

Institute of Bioengineering and Nanotechnology

Agency for Science, Technology

Xin Ding

James L Hedrick

Yi Yan Yang

Nathaniel H Park

Chuan Yang

Zhen Chang Liang

Theodore Gerard Van Kessel

Rudy J Wojtecki

Mareva B Fevre

Amos Cahan

Hariklia Deligianni

Pei-Yun S Hsueh

Mark Kunitomi

Simone Bianco

Jye Yng Teo

Jiayu Leong

Cherylette Anne Alexander

Paola Florez De Sessions

Balamurugan Periaswamy

Yiran Zhen

Jeannette M Garcia

Wei Cheng

Xiang Dong Liu

Techniques regarding a chemical composition that can be utilized within one or more combination therapies to treat a microbial infection are provided. For example, one or more embodiments described herein can comprise a chemical composition that includes a first triblock polymer comprising a quaternary ammonium functionalized polycarbonate block and exhibiting anticancer activity via a lytic mechanism. The chemical composition can also include a second triblock polymer comprising a guanidinium functionalized polycarbonate block and exhibiting anticancer activity via a translocation mechanism.

Combination therapies that enhance antimicrobial/anticancer activities

Techniques regarding treating one or more microbe infections with combination therapy are provided. For example, one or more embodiments described herein can comprise a method, which can comprise enhancing an antimicrobial activity of an antibiotic by a combination therapy. The combination therapy can comprise the antibiotic and a polycarbonate polymer functionalized with a guanidinium functional group.

Utilizing polymers and antibiotics to enhance antimicrobial activity and inhibit antibiotic resistance

Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.

Prevention of biofilm formation

Techniques regarding enhancing antimicrobial activity of antirheumatic agents by combination therapy are provided. For example, one or more embodiments described herein can regard a chemical composition comprising a polycarbonate polymer functionalized with a guanidinium functional group. The chemical composition can also comprise an antirheumatic agent, and the polycarbonate polymer can enhance an antimicrobial activity of the antirheumatic agent.

Combination therapy to achieve enhanced antimicrobial activity

Embodiments are directed to a method of making an antifouling and bactericidal coating with tailorable surface topology. The method includes depositing a layer of branched polyethyleneimine (BPEI) and diamino-functionalized poly(propylene oxide) (PPO) in a mixture of water and organic solvent on a substrate to form a layer of BPEI/PPO. The method includes depositing a layer of glyoxal in a water-containing solution on the layer of BPEI/PPO. The method further includes curing the layer of BPEI/PPO and layer of glyoxal to form a homogenous, glyoxal crosslinked BPEI/PPO coating, where the curing induces local precipitation and alteration of the glyoxal crosslinked BPEI/PPO coating to provide a textured surface.

Tailorable surface topology for antifouling coatings

According to one or more embodiments, a method of making an antifouling coating includes forming a polythioaminal polymer by reacting a fluorinated primary amine with an aldehyde to form an intermediate imine, and then reacting the intermediate imine with a dithiol. The method further includes depositing the polythioaminal on a substrate, and increasing a temperature of the polythioaminal deposited on the substrate to crosslink the polythioaminal and increase a contact angle of the substrate with crosslinked polythioaminal.

Fluorinated networks for anti-fouling surfaces

Catechol-bearing polycarbonates (catechol polymers) were prepared comprising i) a catechol repeat unit comprising a side chain catechol group, ii) a cationic repeat unit comprising a side chain cationic group selected from the group consisting of quaternary amine groups, quaternary phosphine groups, and combinations thereof, and iii) a PEG repeat unit comprising a side chain poly(ethylene oxide) group having a degree of polymerization of about 5 to about 30. The catechol polymers form antimicrobial and antifouling films on a variety of substrate surfaces, in particular silicone rubber.

Antimicrobial and antifouling catechol-containing polycarbonates for medical applications

Antimicrobial, non-hemolytic cationic polyamines were prepared by treating partially N-acylated polyethylenimines and/or partially oxidized polyethylenimines with a protic acid. The cationic polyamines can have a linear or branched polyethylenimine backbone structure. Preferably, the cationic polyamines comprise pendant urea groups, which can be introduced via a cyclic carbonate comprising a pendant urea group. The cationic polyamines can be active against a tuberculosisat low concentration. The cationic polyamines are also effective against Gram-negativeand, Gram-positive, and fungusin solution and in the form of a film.

Antimicrobial cationic polyamines

An antimicrobial silicone rubber comprises a silicone rubber substrate, a catechol layer bound to a surface of the silicone rubber substrate, and an antimicrobial layer disposed on the catechol layer. The catechol layer comprises a catechol material, a quinone derivative thereof, and/or a polymer of the foregoing catechol material and/or quinone derivative. The antimicrobial layer comprises an antimicrobial cationic polycarbonate covalently linked to the catechol layer.

Antimicrobial surface modified silicone rubber and methods of preparation thereof

Apparatus for ultrasonic vibration-assisted machining, the apparatus comprising an ultrasonic transducer for generating ultrasonic waves in a vibration horn; first clamp on the vibration horn at a static node of the ultrasonic waves; and a second clamp between the first clamp and a lowermost end of the vibration horn. The second clamp comprises a linear bearing for reducing vibration of the vibration horn in a direction laterally of the vibration horn, and allowing vibration of the vibration horn in the direction of a longitudinal axial of the vibration horn.

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Xin Ding