Waters Technologies Corporation

Ximo Zhang

Matthew A Lauber

Robert Birdsall

Jennifer M Nguyen

Henry Y Shion

Nilini Ranbaduge

Thomas H Walter

Melvin Blaze Muttikal Thomas

The present disclosure relates to the determination of analytes in a sample using chromatography. The present disclosure provides methods of separating an analyte from a sample. A mobile phase is flowed through a chromatography column. The mobile phase includes about 0.005% (v/v) to about 2.50% (v/v) difluoroacetic acid and less than about 100 ppb of any individual impurity, especially metal impurities. A sample including the analyte is injected into the mobile phase. The analyte is separated from the sample.

Difluoroacetic acid ion pairing reagent for high sensitivity, high resolution LC-MS of biomolecules and small molecules

The present disclosure relates to the determination of analytes in a sample using chromatography. The present disclosure provides methods of separating an analyte from a sample. A mobile phase is flowed through a chromatography column. The mobile phase includes about 0.005% (v/v) to about 0.20% (v/v) difluoroacetic acid and less than about 100 ppb of any individual metal impurity. A sample including the analyte is injected into the mobile phase. The analyte is separated from the sample.

Difluoroacetic acid ion pairing reagent for high sensitivity, high resolution LC-MS of biomolecules

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Framingham, MA, United States of America

Ximo Zhang