University of Kentucky Research Foundation

Ohio State Innovation Foundation

Xijun Piao

Peixuan Guo

Dan Shu

Yi Shu

Mehdi Rajabi

Mario Vieweger

Hongran Yin

Xin Li

Sijin Guo

Disclosed herein are high Tm RNA nanostructures that can be composed of one or more modules or motifs to build RNA nanostructures with or without layers. The RNA nanostructures can have a core domain and three or more double-stranded arms and formulations thereof to conjugate high copy numbers of therapeutics, pH responsive or enzyme cleavable drug cargo. Also described herein is a design strategy for generation of synthetic RNA oligonucleotides that can self assemble into highly thermostable RNA structures. Also described herein are uses of the RNA nanostructures described herein.

RNA nanostructures, methods of making, and uses thereof

Growing community of inventors

San Diego, CA, United States of America

Xijun Piao