Syz Cell Therapy Co.

Hryz (shenzhen) Biotech Co.

Hry Z (guangzhou) Biotech Co.

Hry Z (shanghai) Biotech Co.

Xihe Chen

Xiangjun Zhou

Yanyan Han

Xiaoling Liang

Provided methods of obtaining a plurality of T cell receptors specifically recognizing a target tumor antigen peptide from an individual that has clinically benefitted from an immunotherapy, such as Multiple Antigen Specific Cell Therapy. Also provided tumor-specific TCRs, engineered immune cells expressing the TCRs and methods of treating a disease using the engineered immune cells.

Methods of obtaining tumor-specific T cell receptors

The present application provides methods of preparing tumor antigen-specific T cells comprising enriching activated T cells from a first co-culture comprising a first population of antigen-loaded dendritic cells loaded and a population of T cells, and co-culturing the enriched activated T cells with a second population of antigen-loaded dendritic cells. Also provided are methods of treating cancer in an individual using the tumor antigen-specific T cells, pharmaceutical compositions and kits for cell-based cancer immunotherapy.

Methods of cancer treatment using tumor antigen-specific T cells

Growing community of inventors

Shenzhen, China

Xihe Chen