Janssen Biotech, Inc.

Janssen Sciences Ireland Unlimited Company

Xiefan Lin-Schmidt

Chichi Huang

Judith Ann Connor

Jinquan Luo

Ellen Chi

Ronald Swanson

Galina Obmolova

Jarrat Jordan

Christian Martinez

Lu Lu

Shamina M Rangwala

Jennifer Furman

Serena Nelson

Shannon Mullican

Michael J Hunter

Anthony A Armstrong

Jose Antonio Chavez

Songmao Zheng

Matthew M Rankin

Provided herein are method of using GLP1-GDF15 fusion proteins for reducing food intake, preventing, treating or ameliorating diseases and disorders, such as obesity, type 2 diabetes, the metabolic syndrome, insulin resistance, and dyslipidemia, among others, the fusion protein comprising a GLP1 or GLP1 variant peptide, a first linker peptide, a serum albumin protein, a second linker peptide, and a GDF15 protein.

Glucagon like peptide 1 (GLP1)-growth differentiation factor 15 (GDF15) fusion proteins and uses thereof

Provided herein are GLP1-GDF15 fusion proteins comprising a GLP1 or GLP1 variant peptide, a first linker peptide, a serum albumin protein, a second linker peptide, and a GDF15 protein.

Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions.

GDF15 fusion proteins and uses thereof

The present invention relates to antibodies that broady neutralize interferon-&#x3b1; and interferon-&#x3c9;, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.

Interferon alpha and omega antibody antagonists

Interferon &#x3b1; and &#x3c9; antibody antagonists

Broadly neutralizing interferon-&#x3b1; and interferon-&#x3c9; antibody antagonists, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing are useful in the treatment of diseases associated with increased production of IFN&#x3b1; and IFN&#x3c9;.

Growing community of inventors

Ambler, PA, United States of America

Xiefan Lin-Schmidt