Conjuchem Biotechnologies Inc.

Conjuchem, Inc.

Advanced Diagnostics and Discovery

Xicai Huang

Karen Thibaudeau

Dominique Bridon

Peter G Milner

Martin Robitaille

Roger Leger

Richard Beliveau

Michele Rasamoelisolo

Dominique P Bridon

The present invention relates to a compound comprising a PYY peptide or a functional derivative thereof, which is coupled to a reactive group. Such a reactive group is capable of reacting on a blood component so as to form a stable covalent bond therewith. The present invention also relates to a conjugate comprising such a compound which is covalently bonded to a blood component. Moreover, the invention also relates to a method of enhancing, in a patient, the anti-obesity activity of a PYY peptide or functional derivative thereof.

Anti-obesity agents

Modified anti-angiogenic peptides are disclosed. The modified peptides are capable of forming a peptidase stabilized anti-angiogenic peptide. The modified anti-angiogenic peptides, particularly modified kringle 5 peptides are capable of forming a conjugate with a blood protein. Conjugates are prepared from anti-angiogenic peptides, particularly kringle 5 peptides, by combining the peptide with a reactive functional group with a blood protein. The conjugates may be formed in vivo or ex vivo. The conjugates are administered to patients to provide an anti-angiogenic effect.

Long lasting anti-angiogenic peptides

Growing community of inventors

Kirkland, Canada

Xicai Huang