Westgene Biopharma Co., Ltd

Sichuan University

Medshine Discovery Inc.

Shenzhen Optimum Biological Technology Co., Ltd

Chengdu Jinrui Foundation Biotech Co., Ltd.

Guizhou Inochini Technology Co., Ltd

Westvac Biopharma Co., Ltd.

Jumbo Drug Bank Co., Ltd.

Xiawei Wei

Shuhui Chen

Jian Li

Lei Zhang

Peng Zhang

Fang Liu

Charles Z Ding

Kai Zhou

Yunfu Luo

Guoping Hu

Kevin X Chen

Chengde Wu

Yuquan Wei

Xiangrong Song

Feng Gao

Bin Chen

Lingyun Wu

Chunli Shen

Lele Zhao

Chen Zhang

Zhaoguo Chen

Xuefeng Sun

Xiongbin Xu

Cailin Wang

Boyu Hu

Yanxin Yu

Wei Zheng

Xu You

Ning Jiang

Peng Yang

Min Luo

Wenli Li

Zhaoying Xu

Zhiwei Zhao

Huiyu Zhang

Xia Zhao

The present disclosure relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof, which can be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid.

Ionizable lipids and compositions for nucleic acid delivery

An application of a compound represented by formula (I) and pharmaceutically acceptable salts thereof in preparation of a drug for treating pneumonia.

Application of monocyclic β-lactam compound in pharmacy

A compound as a CXCR2 antagonist and an application thereof in preparing a drug as a CXCR2 antagonist. In particular, the present invention relates to a compound represented by formula (II) or an isomer or pharmaceutically acceptable salt thereof. 

CXCR2 antagonist

The invention belongs to the field of biological medicine, in particular refers to an alhydrogel-sodium chloride compound immunologic adjuvant, preparation method and use thereof. The technical problem to be solved by the invention is to provide a well-behaved and novel immunologic adjuvant. The technical solution for solving the technical problem of the invention is to provide the use of sodium chloride in preparing immunologic adjuvant and the alhydrogel-sodium chloride compound immunologic adjuvant obtained on the basis thereof. The compound immunologic adjuvant mainly includes alhydrogel and sodium chloride. The alhydrogel-sodium chloride compound immunologic adjuvant of the invention is an excellent compound immunologic adjuvant, which can be used for various antigens, and provides a new and effective choice for the development and application of vaccines due to the advantages of simple and convenient use, low cost, strong immune activity, high clinical safety and the like.

Alhydrogel-sodium chloride compound immunologic adjuvant, preparation method and use thereof

Growing community of inventors

Chengdu, China

Xiawei Wei