Johns Hopkins University

Xiaozhong Chen

Natalia A Trayanova

The present invention is directed to a method for determining onset of ventricular arrhythmias using bounded-input bounded-output stability of QT interval (QTI) dynamics. The method of the present invention includes two parts. A first part of the method determines the dependence of each QTI on several prior QTIs and RR intervals (RRI). This determination is represented as an autoregressive model with exogenous input (ARX). A second part of the method determines the BIBO stability of the ARX model in the z-domain. The metrics associated with the first and second parts of the method are then used to predict onset of arrhythmia.

Methodology for assessing the bounded-input bounded-output instability in QT interval dynamics: application to clinical ECG with ventricular tachycardia

A method of predicting ventricular arrhythmias includes receiving an electrical signal from a subject's heart for a plurality of heart beats, identifying characteristic intervals and heart beat durations of the electrical signal corresponding to each of the plurality of heart beats to provide a plurality of characteristic intervals with corresponding heart beat durations, representing dynamics of the plurality of characteristic intervals as a function of a plurality of preceding characteristic intervals and durations of corresponding heart beats over a chosen period time, assessing a stability of the function over the chosen period of time, and predicting ventricular arrhythmias based on detected instabilities in the dynamics of the characteristic intervals.

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Hoover, AL, United States of America

Xiaozhong Chen