Zhejiang Hisun Pharmaceutical Co., Ltd.

Central South University

Xiaoyu Liu

Hua Bai

Xiaohe Zheng

Xuyang Zhao

Qifeng Zhu

Lifei Liu

Yi Bu Li

Bin Liu

Yi Li

Yongxiang Gong

Jinqing Zhong

Peng Sun

Xiaojie Xu

Yuncai Zhang

Zhenliang Chen

Maojian Gu

Yong Zhang

Hairong Luo

Hegeng Wei

Yingqiu Wu

Lifeng Cai

Yaping Wang

Xiaodong Hu

Jian Hong

Guojun Zheng

Hongyan Li

Qixian Zhou

Niefang Yu

Chunhua Jin

Shoufeng Ming

Ying Chen

The present invention discloses a 4-((substituted phenyl)difluoromethyl)phenoxycarboxylic acid derivative and preparation process and use thereof. More specifically, the present invention relates to a compound of the following formula I, which is defined in the specification. The compounds according to the present invention can be used as PPAR agonists, and demonstrates a strong effect on reducing the levels of total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) in blood plasma, and thus the compound according to the present invention can be used in the preparation of a medicament for treating or preventing hyperlipoidemia or cardio-cerebrovascular diseases caused by hyperlipoidemia, such as diabetes, atherosclerosis, stroke, coronary heart disease, etc. The present invention also relates to a novel intermediate compound for the preparation of the compound of formula I and preparation method thereof.

4-((substituted phenyl) difluoromethyl) phenoxy carboxylic acid derivative, and preparation method and uses thereof

Provided in the present invention are novel benzodioxole derivatives and preparation methods thereof. These compounds represented by formula (I) or pharmaceutically acceptable salts thereof have acetylcholinesterase inhibitory activity, so can be used in the treatment or prevention of Alzheimer's disease. The definitions of R, Rand A of formula (I) can be seen in the description. 

Benzodioxole derivative and preparation method and use thereof

Phenyl propanoic acid compounds having activating effect on peroxisome proliferator-activated receptors (PPAR&#x3b1;,&#x3b4;,&#x3b3;) and a preparation method and uses thereof are provided in the present invention. The compounds can be used for treating or preventing diseases associated with peroxisome proliferator-activated receptors (PPAR&#x3b1;,&#x3b4;,&#x3b3;).

Compounds having activating effect on subtypes of peroxisome proliferator-activated receptors and its preparation method and uses

Provided are a benzamide derivative as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the preparation method and use thereof for preparing a medicine for treating cancer, wherein the group definitions of formula (I) are as set out in the description. 

Benzamide derivative with anticancer activity and preparation method and use thereof

The present invention relates to compounds represented by formula (I) or composition comprising at least one of such compounds, which are inhibitors of histone deacetylase. The detailed description of these compounds is disclosed in the Description. These compounds and the composition comprising the same may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase (HDAC) activities.

Histone deacetylase inhibitors, process for preparation and uses thereof

The present invention provides a novel compound of formula I, which has an agitation effect on the peroxisome proliferator-activated receptor subtype &#x3b4; (PPAR&#x3b4;), to a pharmaceutical composition comprising the compound, to a process for preparation of the compound and to use of the compound in the manufacture of a medicament for treating or preventing a disease which could be treated or prevented by activating PPAR&#x3b4; thereof, said disease is one or more from the group comprising metabolic syndrome, obesity, dyslipidemia, pathoglycemia, insulin resistance, senile dementia and tumors. The present invention also relates to a new intermediate used in the preparation of the novel compound and a process for preparation of the intermediate. 

Compound with agitation effect on peroxisome proliferator-activated receptor process for its preparation and use thereof

Preparation of azetidinone compounds and medical use thereof are provided by the present invention. More particularly, azetidionne compounds, shown as formula (I), wherein R, R, R, R, Rand Rare defined in description, and preparation methods thereof are provided by the present invention. The compounds of the present invention can reduce the levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in plasma, and can be used as medicaments for reducing cholesterol in blood. Therefore the compounds of the present invention can be used to treat or prevent diseases of atherosclerosis, cacergasia of blood vessel, cardiac failure, coronary artery disease, angiocardiopathy, myocardial, angina, hyperlipoidemia and hypercholesteremia and the like. Preparation method of compounds of formula (I) and intermediate compounds are also provided by the present invention. 

Azetidinone compounds and medical use thereof

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Taizhou, China

Xiaoyu Liu