Onkure, Inc.

Shanghai Sta Pharmaceutical R&d Co., Ltd.

Shanghai Sta Pharmaceutical Product Co., Ltd.

Shanghai Syntheall Pharmaceuticals Co., Ltd.

Xiaoyong Fu

Anthony D Piscopio

Feng Shi

Zhifeng Li

Huayan Liu

Abdolsamad Tadayon

Donglin Li

Zhenbing Zhao

Like Chen

Ruiheng Zhu

Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R-R, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.

Process for the preparation of cyclic depsipeptides

Disclosed is an LED light source photocatalytic tubular reactor and application thereof. The LED light source photocatalytic tubular reactor comprises an LED light source, a temperature control chamber and a transparent reaction pipeline; the transparent reaction pipeline is located in the temperature control chamber; at least one side of the temperature control chamber is a light-transmitting plate; the LED light source provides a light source for the transparent reaction pipeline through the light-transmitting plate; and the transparent reaction pipeline has a diameter-to-length ratio of the inner diameter to the length of 0-0.1, but not 0. The LED light source continuous photocatalytic tubular reactor of the present disclosure can eliminate the scaling up effect, increase the yield and allow continuous production with an advantage of easy to use and low cost. The tubular reaction device of the present disclosure can also realize automatic control, which can effectively reduce personnel costs and improve production safety.

LED light source photocatalytic tubular reactor and application thereof

Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R-R, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described. 

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Shanghai, China

Xiaoyong Fu