The University of Texas System

Xiaoyan Zhou

Dihua Yu

Mien-Chie Hung

Jun Yang

Wentao Yang

Ping Li

Jun Yao

Yoichi Nagata

Christopher L Neal

Francisco J Esteva

Raphael E Pollock

Aysegul A Sahin

Nina T Nguyen

Patients with ErbB2-overexpressing cancers can be given an ErbB2 targeting agent as a therapeutic regimen but not all patients are responsive. The present invention concerns the diagnostic, prognostic and therapeutic methods and compositions for evaluating potential efficacy of an ErbB2 targeting agent in an ErbB2-overexpressing cancers by evaluating PTEN expression, which is predictive of responsiveness or resistance to ErbB2 targeting agents such as trastuzumab. Low PTEN expression is predictive of a patient who will respond poorly to trastuzumab.

Diagnostic and therapeutic methods and compositions involving PTEN and breast cancer

Methods of determining prognosis in a subject with a hyperproliferative disease, including determining expression and/or function of 14-3-3 zeta in the subject, are disclosed. Also disclosed are methods of making a pharmaceutical agent that modulates apoptosis, including the steps of obtaining one or more candidate, testing the one or more candidate substances to determine their ability to modulate the expression and/or function of 14-3-3 zeta, selecting a candidate substance determined to modulate the expression and/or function of 14-3-3 zeta, and making a pharmaceutical composition that includes the selected candidate substance. In addition, methods of treating a subject with a hyperproliferative disease, including making a pharmaceutical agent by the methods set forth herein, and administering the pharmaceutical agent to a subject, are disclosed. The hyperproliferative disease can be cancer, such as breast cancer.

14-3-3 Zeta over-expression as a poor prognosis factor, and a therapeutic target in multiple cancer type

14-3-3 zeta over-expression as a poor prognosis factor, and a therapeutic target in multiple cancer types

Growing community of inventors

Shanghai, China

Xiaoyan Zhou