Other

Shanghai Jiao Tong University

Perfect Company

Xiaoyan Pang

Liping Zhao

Xu Zhang

Guang Ning

Xiaoying Li

Xiaojun Zhang

Menghui Zhang

Yifei Zhang

Jia Wei

Yufeng Zhao

Linghua Wang

Wei Hua

Dazheng Wu

A method and a composition for improving gut micro biota structure, selectively increase a first gut microbiota population while simultaneously decrease a second gut micro biota population in a subject. The first gut micro biota population includes a short-chain fatty acid (SCFA)-producing bacterium and the second gut microbiota population includes an endotoxin-producing bacterium.

Methods and compositions for improving gut microbiota population

Non-invasive methods for monitoring the effect of an agent for treating colorectal cancer, comprising (1) collecting fecal samples from healthy subjects, subjects having precancerous lesions, and subject having precancerous lesions and being treated with an anti-cancer agent; (2) isolating total microbial genomic DNA from the fecal samples to provide total microbial genomic DNA; (3) comparing the total microbial genomic DNA using fingerprint spectrum analysis; (4) identifying key fingerprint bands correlated with the effect of the anti-cancer agent; (5) identifying key microorganisms associated with the key fingerprint bands; (6) designing microbial sequence-specific primers and probes; and (7) determining the quantitative differences of the key microorganisms in fecal samples to identify an indicator microorganism for monitoring the effect of the anti-cancer agent.

Methods for detecting therapeutic effects of anti-cancer drugs by monitoring changes in gut flora

Growing community of inventors

Shanghai, China

Xiaoyan Pang