California Institute of Technology

Xiaoyan Bao

Stephen R Quake

Todd A Thorsen

Vincent Studer

Sebastian J Maerkl

Melvin I Simon

High-density microfluidic chips contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to electronic integrated circuits fabricated using large scale integration (LSI). A component of these networks is the fluidic multiplexor, which is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs. These integrated microfluidic networks can be used to construct a variety of highly complex microfluidic devices, for example the microfluidic analog of a comparator array, and a microfluidic memory storage device resembling electronic random access memories.

Microfabricated structure having parallel and orthogonal flow channels controlled by row and column multiplexors

A method and a microfluidic device are provided to regulate fluid flow by equalization of channel pressures. The fluid flow is regulated by way of valve-actuated channel pressures.

Method and device for regulating fluid flow in microfluidic devices

Microfluidic large scale integration

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Pasadena, CA, United States of America

Xiaoyan Bao