Abbott Laboratories Corporation

Xiaoxing Qiu

Joan D Tyner

Jeffrey C Hunt

John George Konrath

James W Scheffel

Sheng C Lou

Qiaoqiao Ruan

Sergey Y Tetin

Mark R Pope

Kerry M Swift

Brenda Calfin

Patrick J Macdonald

Dominique P Bridon

Barry Lee Dowell

John R Hackett

John C Prostko

Zhen Lin

M Felicia Bogdan

Priscilla Swanson

Richard Haack

Ka-Cheung X Luk

Kim Sverker Pettersson

Mauno Antero Vihinen

Timo Petteri Piironen

Hans Lilja

John G Konrath

The disclosure provides methods of analyzing an analyte of interest in a biological sample using fluorescent agents and macroconjugates which comprise a core containing a cross-linked polymer or protein, tags, specific binding members or fragments thereof, and optionally carrier proteins. Also provided are methods of analyzing two or more analytes of interest in a biological sample in a single assay using microparticles and detection conjugates comprising different fluorophore labels, acquiring transmitted light and fluorescent images of the microparticles, and using a customized image analysis process to analyze the acquired images.

Direct detection of single molecules on microparticles

The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample.

Monoclonal antibodies to human immunodeficiency virus and uses thereof

The present invention relates generally to assays for the detection of Xenotropic Murine Leukemia Virus-related Retrovirus ('XMRV') and diseases associated with XMRV infection. Additionally, the invention relates to specific XMRV antigens capable of inducing an immunogenic response as well as XMRV-related nucleic acids having significant diagnostic, screening, and therapeutic utilities.

Markers of XMRV infection and uses thereof

Methods for the detection of HIV-1 or -2 antigens employing monoclonal antibodies that recognize a shared HIV-1/-2 epitope in the capsid p24/p26 proteins

Monoclonal antibodies that recognize a shared epitope between the human immunodeficiency virus type 1 (HIV-1) capsid (CA/p24) and the human immunodeficiency virus type 2 (HIV-2) capsid (CA/p26)

Monoclonal antibodies that recognize a shared epitope between the human immunodeficiency virus type 1 (HIV-1) capsid (CA/p24) and the human immunodeficiency virus type 2 (HIV-2) capsid (CA/p26).

The present invention relates to peptides which may be used, for example, in the detection of free and complexed Prostate Specific Antigen and thus in the diagnosis of prostate cancer.

Prostate specific antigen peptides and uses thereof

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Gurnee, IL, United States of America

Xiaoxing Qiu