Xiamen University

Hongyun Biotech Co., Ltd.

Xiaoxing Huang

Xianming Deng

Zhiyu Hu

Zhou Deng

Wei Peng Huang

Shuang Liu

Ting Zhang

Xihuan Sun

Li Li

Qingyan Xu

Yan Liu

Baoding Zhang

Chao Dong

Wei Huang

Yunzhan Li

Yue Lu

Zhongji Zhuang

The present invention relates to thienopyrimidine compound, preparation method thereof, pharmaceutical composition and use thereof, and in particular to a type of compounds having ALK and/or c-Met selective inhibitory activity, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with anaplastic lymphoma kinase in vivo, and in the manufacture of a medicament for preventing or treating a disease associated with angiogenesis or cancer metastasis, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis. 

Thienopyrimidine compound, preparation method thereof, pharmaceutical composition and application thereof

The present invention relates to a compound of formula I, a stereoisomer, a prodrug, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, and a process for preparing the same, a pharmaceutical composition comprising the same, and use of the compound in the preparation of medicine preventing and treating tumors, wherein the substituents are as defined in the specification. 

Pyrimidopyrrole compounds, method for preparing the same, pharmaceutical compositions comprising the same and uses thereof

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Xiamen, China

Xiaoxing Huang