Instrumentation Laboratory Company

Xiaoxian Xu

Prasad Pamidi

Jose Cervera

Miklos Erdosy

David Raimondi

Hyoungsik Yim

Ruchika Malhotra

Matthew Curley

Techniques includes measuring, using a creatine sensor, a creatine sensor current signal (ΔI2) of a first calibration solution (CS2). A creatine sensor sensitivity (Slope) for the creatine sensor is based on the creatine sensor current signal (ΔI2). The first calibration solution (CS2) has a known concentration of creatine (CR_CS2), a known concentration of creatinine (CREA_CS2), and a stable ratio of creatine to creatinine over a range of temperatures for a predefined shelf-life of the first calibration solution (CS2). The Techniques include measuring, using the creatine sensor, a measured creatine concentration (MCR_CS3) of a second calibration solution (CS3). The second calibration solution (CS3) has an initial known creatine concentration (CR_CS3), an initial known creatinine concentration (CREA_CS3), and an unstable ratio of creatine to creatinine that changes over the predefined shelf-life. Concentrations of creatine and creatinine in a sample are thereafter estimated.

Compositions and methods for improved calibration accuracy of creatinine/creatine sensors and uses thereof

Disclosed herein are compositions for permeable outer diffusion control membranes for creatinine and creatine sensors and methods of making such membranes.

Outer membrane compositions for creatinine/creatine sensors

Disclosed is a urea biosensor that is stable at ambient temperature, and methods of making thereof.

Urea biosensors and stabilization of urea biosensors at room temperature

The disclosure relates to electrochemical sensors for measuring creatinine and creatine in a patient's blood. More particularly, the disclosure relates to compositions and methods for improving measurement accuracy of electrochemical sensors used for measuring creatinine and creatine.

Compositions and methods for improved creatinine measurement accuracy and uses thereof

Disclosed are multi-enzyme biosensors that are stable at ambient temperature, and methods of making thereof.

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Maynard, MA, United States of America

Xiaoxian Xu