Chinese Academy of Medical Sciences

Beijing Jiuyu Oncolgy Co., Ltd.

Xiaowen Xing

Zhiqiang Liu

Zengqiang Yuan

Shihong Liu

Bingshui Xiu

Cui Wang

An application of hyaluronic acid in preparing medicines for preventing or treating ferroptosis-related diseases is provided, and an application of hyaluronic acid or salts of hyaluronic acid or derivatives of hyaluronic acid in preparing medicines for inhibiting ferroptosis is also provided. According to the present application, the anti-ferroptosis function of hyaluronic acid is disclosed. The hyaluronic acid is the first natural extracellular matrix material with anti-ferroptosis function found at present. The hyaluronic acid is one of the components of natural extracellular matrix and exists in large quantities in human body and is also a widely used material in clinic.

Application of hyaluronic acid in preparing medicines for preventing or treating ferroptosis-related diseases

A fusion imaging gene and lentiviral expression plasmid, lentivirus and cell, and preparation methods and applications thereof are provided. The fusion imaging gene includes bioluminescence imaging gene, fluorescent protein gene and calcium imaging gene. The three genes are linked by linkers. The fusion gene is inserted into a modified lentiviral expression plasmid to obtain lentivirus particles carrying the fusion imaging gene.

Fusion imaging gene and lentiviral expression plasmid, lentivirus, cell, preparation methods and applications thereof

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Beijing, China

Xiaowen Xing