Covidien LP

Nantbioscience, Inc.

Becton Dickinson and Company Limited

Abraxis Bioscience, LLC

Nantbio, Inc.

Xiaowen Sun

Neil P Desai

Chunlin Tao

Wei Zhang

Shouwei Li

Fen Du

Yezhou Wu

David G Ho

Qinwei Wang

Laxman Nallan

Tulay Polat

Hongna Han

Patrick Soon-Shiong

Zhixiu He

Neville Chia

Lukasz Koroniak

A surgical stapling device includes a staple reload and a handle assembly that supports a drive rack, a motor assembly, a gear assembly, a reload select mechanism, and a safety toggle mechanism. The gear assembly is adapted to facilitate uncoupling of the motor assembly from the drive rack to allow manual movement of the drive rack. The reload select mechanism allows the length of a stroke of the drive rack to be selectively adjusted to allow the stapling device to accommodate different length staple reloads. The safety toggle mechanism is provided to move the stapling device from a non-firing state to a firing state to allow for firing of the stapling device.

Surgical stapling device with powered handle assembly

A needle-tract assistants () for establishing a needle tract of a predetermined length, including a needle thruster () and a needle-in-catheter assembly () removably loaded in the needle thruster (). The needle thruster () can include a cradle (), a carriage() within the cradle (), and a plunger () coupled to the carriages (). The carriages () can be configured to move between a proximal-end portion and a distal-end portion of the cradle(). The plungers () can be configured to move the carriages () within the cradle(). The plungers () can also be configured to allow a user to set the predetermined length of the needle tract before establishing the needle tract. The needle-in-catheter assembly () can include a hub (), a catheter tube () extending from a distal-end portion of the hub (), and a needle () disposed within the catheter tube (). Also described are components of the needle-tract assistants () and methods of the needle-tract assistants () or the components thereof.

Needle-tract assistant including components and methods thereof

The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.

Benzyl substituted triazine derivatives and their therapeutical applications

The invention provides isoquinoline, quinoline, and quinazoline derivatives to treat a variety of disorders, diseases and pathologic conditions, and more specifically to the use of isoquinoline, quinoline, and quinazoline derivatives to inhibit the hedgehog signaling pathway and to the use of those compounds to the treatment of hyperproliferative diseases and pathologic angiogenesis.

Isoquinoline, quinoline, and quinazoline derivatives as inhibitors of hedgehog signaling

Analogs of geldanamycin (an ansamycin), pharmaceutical formulations comprising such analogs, and methods of use (e.g., treating tumors).

Analogs of ansamycin and pharmaceutical compositions thereof

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Shanghai, China

Xiaowen Sun