Ecovacs Robotics Co., Ltd.

Jiangxi Caishi Pharmaceutical Technology Co., Ltd.

Xiaowen Li

Pingxing Huang

Fang He

Xintong Yu

Jinye Zhou

XiaoJuan Chen

Li Chen

Mengdan Chen

Jingyi Cao

Qing Shao

Jingya Xie

Xiaojian Xue

Robotic cleaner

The present disclosure belongs to the field of medicinal chemistry, and relates to a novel pyridone derivative represented by Formula (I) or a stereoisomer, a pharmaceutically acceptable salt, a solvate or a crystal thereof, and use thereof in the preparation of a drug for preventing or treating diseases such as influenza type A viral infection and/or influenza type B viral infection, particularly use thereof as a PA subunit cap-dependent endonuclease inhibitor for preventing or treating diseases such as influenza type A viral infection and/or influenza type B viral infection. The compounds of the present disclosure have significant activity in inhibiting influenza endonuclease and influenza DNA, can be used either alone or in combination with a neuraminidase inhibitor, a nucleoside drug, a PB2 inhibitor, a PB1 inhibitor, an M2 inhibitor or other anti-influenza drugs, significantly shorten the time of influenza infection and reduces mortality, and have excellent clinical application prospects. 

Pyridone derivative, composition and use as antiviral drug thereof

Robot cleaner

Suction device

Growing community of inventors

Nanjing, China

Xiaowen Li