Shanghai Institute of Pharmaceutical Industry

Nhwa Pharma. Corporation

Shanghai Zhongze Therapeutics, Co. Ltd.

Xiaowen Chen

Jianqi Li

Fang Liu

Guan Zhong Wang

Guisen Zhang

Xiangqing Xu

Minquan Yu

Yali Li

Song Zhao

Shicheng Liu

Junwei Xu

Zhilong Ma

Ning Cui

Yangli Qi

Ruixiang Yuan

Qiang Pu

Disclosed in the present invention are a pyridinyl morpholine compound, a preparation method therefor, and an application thereof. The present invention provides a pyridinyl morpholine compound as represented by formula I, a pharmaceutically acceptable salt thereof or a hydrate of the pharmaceutically acceptable salt thereof. The compound can be used as an antagonist for one or more of D, Dor 5-HT, and is used for preparing a drug for treating schizophrenia.

Pyridinyl morpholine compound, preparation method therefor, and application thereof

Disclosed are benzoisothiazole compounds and a use in the preparation of anti-schizophrenia drugs. The benzoisothiazole compounds of the present invention not only have strong affinity for dopamine Dreceptor, 5-HTreceptor and 5-HTreceptor, but also can observably improve the symptoms of schizophrenia relevant to apomorphine model and MK-801 model mice, with oral absorption being good, safety being high and side-effect being less, and having developmental value as new anti-neurotic disease drugs. The present invention is the compounds having a structure of general formula (I), or geometric isomers, free alkalies, salts, hydrates or solvates thereof. 

Benzoisothiazole compounds and methods of treating schizophrenia

Disclosed in the present invention is a 3-cyanoanilinoalkylarylpiperazine derivatives and use thereof in preparing drugs; the 3-cyanoanilinoalkylarylpiperazine derivatives disclosed by the present invention has very useful pharmaceutical properties and good tolerance, especially the use as novel analgesic drugs, novel antidepressants, and novel analgesic and antidepressive drugs. This class of compounds are central analgesics regulating 5-hydroxytrptamine, and also are novel antidepressants regulating 5-hydroxytrptamine. This class of compounds also has less toxic and side effects and a higher safety range. The 3-cyanoanilinoalkylarylpiperazine derivative is a compound shown as formula (III) or free base or salt thereof: 

3-cyanoanilinoalkylarylpiperazine derivative and use thereof in preparing drugs

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Shanghai, China

Xiaowen Chen