Shanghai Jmt-bio Technology Co., Ltd.

Xiaotian Cui

Jian Wang

Tao Li

Hong Xu

Kai Long

Yi Fan

Liping Song

Yisha She

Haixiang Wu

Jiana Jia

Ganliang Zhang

Provided is a bispecific recombinant protein, comprising a high affinity tumor-targeting arm and a low affinity fusion protein blocking the interaction of CD47 with SIRP&#x3b1;. The antibody corresponding to the high affinity tumor-targeting arm does not bind to CD47, and its binding affinity to the target antigen on the tumor cell is at least 6 times as great as the binding affinity of monomer fusion protein homodimer corresponding to the low affinity fusion protein blocking the interaction of CD47 with SIRP&#x3b1;, to a CD47 on the tumor cell, wherein the low affinity fusion protein blocking the interaction of CD47 with SIRP&#x3b1; comprises a SIRP&#x3b1; extracellular truncation. Also provided are nucleic acid molecules encoding recombinant proteins and the use of the recombinant proteins and nucleic acid molecules in the manufacture of a medicament for treating tumors.

Bispecific recombinant protein and use thereof

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Shanghai, China

Xiaotian Cui