Jiangsu Hengrui Medicine Company Ltd.

Shanghai Hengrui Pharmaceutical Co., Ltd.

Xiaotao Li

Qing Dong

Jiong Lan

Bonian Liu

Xuejun Zhang

Yaoping Zhu

Piaoyang Sun

Qiyue Hu

Guoqing Cao

Jianbiao Peng

Fangfang Jin

Chunyan Gu

Chunzhou Han

A pyrrole six-membered heteroaryl ring derivative, and the medicinal uses thereof are described. Specifically, the pyrrole six-membered heteroaryl ring derivative is a compound of formula (I), wherein the variable groups are as described in the specification. 

Pyrrole heteroaryl ring derivative and method of use thereof

Cycloalkyl acid derivatives, a preparation method thereof, and a pharmaceutical application thereof are described. In particular, a cycloalkyl acid derivative represented by general formula (I) and a medical salt thereof, a preparation method thereof, and an application of the cycloalkyl acid derivative and the medical salt thereof as URAT1 inhibitors, and particularly as therapeutic agents for diseases related to an abnormal uric acid level are described, wherein definitions of substituent groups in general formula (I) are the same as the definitions in the specification. 

Cycloalkyl acid derivative, preparation method thereof, and pharmaceutical application thereof

The present invention relates to a pyrrole six-membered heteroaryl ring derivative, the preparation method therefor, and the medicinal uses thereof. Specifically, the present invention relates to a new pyrrole six-membered heteroaryl ring derivative as represented by formula (I), the preparation method therefor, a medicinal composition comprising the derivative, and a therapeutic method using same, and, in particular, the uses as a JAK inhibitor and an immunosuppressor. Substituents in formula (I) have the same definitions as in the description. 

Pyrrole six-membered heteroaryl ring derivative, preparation method thereof, and medicinal uses thereof

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Shanghai, China

Xiaotao Li