Merck Sharp + Dohme Corp.

Xiaoqing Han

Subharekha Raghavan

Jian Guo

Alan Whitehead

Jonathan A Groeper

Yong Zhang

Brian Alexander McKittrick

Sung-Sau So

Emma R Parmee

Zhicai Wu

Sherman Tim Waddell

Peter Orth

Cameron James Smith

Linda Brockunier

Shouwu Miao

Xibin Liao

Yi-Heng Chen

Jiang Chang

Jacqueline D Hicks

John E Stelmach

Brent Whitehead

Hong Li

Jerry Andrew Taylor

Joie Garfunkle

Hong Dong Chu

Keith Rosauer

Olga Ornoski

Matthew Lombardo

Timothy A Cernak

Spencer Dreher

Linda L Brockunier

Olga A Ornoski

Brent R Whitehead

The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIIa inhibitors. 

Factor XIIa inhibitors

A compound of Formula I or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate ('cGMP') and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I, or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula I or a pharmaceutically acceptable salt thereof. 

Soluble guanylate cyclase activators

A compound of Formula I or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate ('cGMP') and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I, or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula I or a pharmaceutically acceptable salt thereof.

A compound of Formula (I): or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate ('cGMP') and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I, or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula (I) or a pharmaceutically acceptable salt thereof. 

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Edison, NJ, United States of America

Xiaoqing Han