Reach Surgical Inc.

Tianjin Agricultural University

Xiaoqiang Chen

Zhenzhen Xu

Ming Li

Yao Zhan

Shoujun Sun

Gaoyi Cao

Xiaodong Xie

Bo Ding

Disclosed is a surgical instrument having an interlock mechanism, and the surgical instrument includes a handle portion having a handle housing; an elongated body, defining a longitudinal axis of the instrument; an end effector, arranged on distal portion of the elongated body for operating tissues; a rotatable sleeve, circumferentially fixed with proximal portion of the elongated body and provided with a plurality of teeth; a rotatable knob, operatively to be reciprocated along the longitudinal axis; and an articulation gear assembly including an annular gear and a planet gear assembly.

Surgical instrument having interlocking mechanism

A surgical instrument has an interlocking function and includes an end effector, an elongated portion and a handle portion. Two ends of the elongated portion are respectively connected to the end effector and the handle portion. The handle portion includes a handle housing, a rotatable knob arranged on a distal portion of the handle portion and operatively to be reciprocated along the longitudinal direction of the elongated portion, and a locking assembly including at least one slide member and a lockout gear. The slide member is arranged between the rotatable knob and the handle housing, and axially fixed with the rotatable knob so as to be reciprocated with the rotatable head for being operatively engaged with the slide member. The slide member is circumferentially fixed with the handle portion, and the lockout gear is rigidly mounted at a proximal portion of the elongated portion. The safety of the surgical instrument may be improved due to high structural stability and high stability between components.

This invention relates to an artificial salt tolerant protein NLEA with the amino acid sequence shown in SEQ ID No.1 and a synthetic method of salt tolerant protein NLEA comprising the steps of retrieving different types of LEA proteins from LEA database; making multiple sequence alignment on different types of LEA proteins to obtain conserved short peptides; selecting hydrophilic short peptides with a hydrophilicity index higher than 3.5 from conserved short peptides; arranging and splicing hydrophilic short peptides in the order of isoelectric point size from large to small, to obtain salt tolerant protein NLEA. This invention involves bioinformatics analysis by retrieving different LEA conserved amino acid sequences of LEA protein data. Physical properties are analyzed to find short peptides of high hydrophilicity, and such short peptides are arranged in the order of isoelectric point size and spliced to get a new hydrophilic amino acid sequence.

Artificial salt tolerant protein, its synthetic method and coding gene thereof and use of said coding gene

Growing community of inventors

Tianjin, China

Xiaoqiang Chen