Shanghai Ennovabio Pharmaceuticals Co., Ltd.

Ennovabio (zhejiang) Pharmaceuticals Co., Ltd.

Xiaoping Xie

Lei Jiang

Yuan Xu

Ke Shang

Haixia Zhao

Jianwen Deng

Shengyang Liu

Zhiyong Feng

Xueli Xu

Zhi Qiao

Jianhua Zhang

Mingwei Zheng

Jianyong Shou

Danyi Wu

Xudong Mao

The present invention provides preparation of a semicarbazide-sensitive amine oxidase inhibitor and use thereof. In particular, disclosed in the present invention are a compound as represented by formula I, or a stereoisomer or a racemate or a pharmaceutically acceptable salt of the compound. Also disclosed in the present invention is that the compound can inhibit semicarbazide-sensitive amine oxidase.

Preparation of semicarbazide-sensitive amine oxidase inhibitor and use thereof

Provided are a preparation of semicarbazide-sensitive amine oxidase inhibitor and the use thereof. In particular, disclosed are a compound as shown in formula I, or a stereoisomer or racemate or pharmaceutically acceptable salt thereof. Also disclosed is that the above-mentioned compound can inhibit semicarbazide-sensitive amine oxidase.

Preparation of seimicarbazide-sensitive amine oxidase inhibitor and use thereof

Provided are a JAK kinase inhibitor, preparation and use thereof. In particular, provided is a compound of Formula I, wherein each group is as described in the specification. The compound has an excellent JAK inhibitory activity, and therefore can be used to prepare pharmaceutical compositions for the treatment of cancer and other diseases related to JAK activity.

Aromatic heterocyclic compound with kinase inhibitory activity

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Shanghai, China

Xiaoping Xie