Shanghai Electrician Industry & Commerce Co., Ltd.

Shanghai Puhe Technology Co., Ltd.

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Lianyungang Runzhong Pharmaceutical Co., Ltd.

Shanghai Dude Medical Science and Technology Co., Ltd.

Xiaoping Chen

Haifeng Pan

Xiquan Zhang

Xin Liu

Aiming Zhang

Xingdong Cheng

Leilei Yang

Rui Kong

Shan Chen

The present application relates to a method for preparing Ibutinib as shown by the following synthetic route and the intermediate compounds involved therein. 

Process for preparing ibrutinib

A position lock and position shift controlling mechanism for a multi-position shifting switch includes a position lock and position shift assembly and a controlling assembly to control the locking of the position lock and position shift assembly. The position lock assembly includes a locked body, a moving body and a housing body. The locked body includes a roundel pedestal which rotates synchronously with a switching shaft, a lock tooth component rotatably attached with the roundel pedestal, and an inner core component. The lock tooth component includes evenly distributed location teeth and plural radial slots. The moving body locks the lock tooth component and pushes the inner core component away from the lock tooth component. The switching shaft actuates the roundel pedestal to rotate a preset angle about the lock tooth component to shift the multi-position shifting switch to a stop control mode position from an automation control mode position.

Position locking and shifting control mechanism

A skeleton unit to mount mosaic plates, includes a main body section and an extension section. The main body section is integrally formed by strip pieces perpendicularly crossing each other to provide a grille shape. The extension section extends out from four edges of the main body section and is integrally formed with the main body section. The extension section includes prolongation pieces which respectively extend out from both ends of each strip piece, and parallel strips which connect with the outside ends of each prolongation piece on the same side and are in parallel with the edges of the main body section respectively. The parallel strip has lap joint hole portions, which penetrates the parallel strips and are used to overlap another skeleton unit. The sum of double the length of the prolongation piece and the width of the parallel strip is equal to the length of the grid.

Skeleton unit and skeleton unit assembly

Growing community of inventors

Shanghai, China

Xiaoping Chen