Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Centaurus Biopharma Co., Ltd.

Lianyungang Runzhong Pharmaceutical Co., Ltd.

Xiaopeng Guo

Xiquan Zhang

Aiming Zhang

Lin Liu

Chunguang Xia

Guangming Sang

Rui Zhao

Gang Wu

Xingjian Zhou

Jiabin Qiao

The present application relates to a method for preparing trifluridine, comprising reacting a compound of formula III with a compound of formula IV in a first solvent in the presence of an acid to obtain a compound of formula II, and performing further reaction to obtain trifluridine.

Method for preparing trifluridine

The present application relates to a crystal of a compound represented by Formula (I), a salt thereof, and a crystal of the salt thereof, a method for preparing the crystal of the compound represented by Formula (I), the salt thereof, and the crystal of the salt thereof, a crystal comprising the compound represented by Formula (I), a crystal composition comprising the crystal of the salt thereof, a pharmaceutical composition thereof, and medical uses thereof. 

Crystal of DPP-IV long-acting inhibitor and salt

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Jiangsu, China

Xiaopeng Guo