Other

Shanghai Changzheng Hospital

Xiaopan Cai

Jianru Xiao

Hong Ding

Shungui Chen

Tielong Liu

Siwang Hu

Wanwan Shen

Yiyun Cheng

The present application relates to the technical field of medical instruments and provides an anti-loosening medical screw based on an organism osteogenesis function. The medical anti-loosening screw comprises a screw cap and a screw rod connected to the screw cap. The screw rod comprises a main rod and a thread spirally wound around the main rod. The cross section of the main rod is non-circular. The present medical anti-loosening screw based on an organism osteogenesis function can be applied to the medical fields such as orthopedics (spine, four limbs, pelvis, joints, etc.), maxillofacial surgery, odontology, and veterinarians and can be effectively prevented from loosening after operation after being implanted.

Medical anti-loosening screw based on organism osteogenesis function

A composition for gene therapy or transfection includes nucleic acid, natural polyphenol, and cationic molecules. There are several phenolic hydroxyl groups in the natural polyphenol, so as to eliminate free radicals, prevent cancer, fight inflammation, and provide antioxidants feature. Compared with the delivery of cationic molecules alone, the composition can significantly improve the transfection efficiency by about 60-70%, reduce the dose of effective transfection of cationic molecules by about 20 times, thereby reducing the toxicity of transfection and showing better organism compatibility. The composition of the present invention does not introduce other chemical reagents, does not require synthesis, has high biosafety, and can efficiently and safely deliver a plurality of nucleic acid molecules into cells. The composition can be used as a highly effective and low-toxicity nucleic acid drug in the treatment of gene-related diseases, and has good medicinal value.

Composition for gene therapy or transfection, and preparation method and use thereof

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Shanghai, China

Xiaopan Cai