Chinese Academy of Medical Sciences

Xiaonan Du

Yucheng Wang

Mei Zhu

Minghua Wang

Xuefu You

Juxian Wang

Guoning Zhang

The present disclosure is related to the field of enzyme inhibitors, and in particular to a hydroxamic acid derivative, a method for producing the same and use thereof. The hydroxamic acid group of the hydroxamic acid derivative can be chelated with zinc ions in the LpxC active area, and the derivative has a hydrophobic side chain which can bind to hydrophic channels in the enzyme LpxC. These guarantee that the hydroxamic acid derivative has good bactericidal activity against Gram-negative bacteria and low toxicity. The present disclosure also provides a method for producing the hydroxamic acid derivative, which requires a shorter reaction time and can provide the derivative with a high yield.

Hydroxamic acid derivative, method for producing same and use thereof

A method for weakening delays resulted from failures of multiple continuous nodes in a DBFT distributed network is provided. In step S, whether a view index is equal to zero is determined, if yes, a new Leader index is obtained according to a first rule and the method processes to step S, otherwise processes to step S. In step S, the new Leader index is obtained according to a second rule, and whether a proposal proposed by a node corresponding to the new Leader index is passed is determined. If yes, the method processes to step S, otherwise, step Sis implemented repeatedly until the proposal proposed by the node corresponding to the new Leader index is passed. In step S, the node corresponding to the new Leader index is taken as a new Leader. Then the delays caused by multiple continuous nodes in the DBFT distributed network are weaken.

Method for weakening delays resulted from failures of multiple continuous nodes in DBFT, computer readable storage medium and DBFT distributed network

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Beijing, China

Xiaonan Du