Ca, Inc.

Beijing University of Agriculture

Xiaomeng Zhao

Xin Wang

Yan Wang

Jing Li

Zheng Wang

Bowen Yang

Can Liu

Tianyu Jia

Long Rong

Dahan Gong

Juntao Li

Zhengzi Bi

Shuai Gou

Yuanxia Sun

Xiaozhu Bi

Lanqing Ma

Haiwen Hu

Dequan Dou

Di Sang

The present invention relates to a chemical and pharmaceutical technology, and in particular to a STAT3 and ERK signal pathway inhibitor and a use thereof. The present invention provides a STAT3 and ERK signal pathway inhibitor. The inhibitor mainly consists of a mogroside and/or an analog thereof. The mogroside and the analog thereof inhibit the phosphorylation of a transcription factor STAT3 and the phosphorylation of an ERK. The method for preparing the mogroside and the analog has the characteristics of simpleness, strong operability and high purity of products. The present invention further provides a use of the STAT3 and ERK signal pathway inhibitor in the preparation of drugs for treating tumors, which realizes the purposes of inhibiting the proliferation of cancer cells and promoting the apoptosis of cancer cells and has a very good inhibition effect on cancers.

STAT3 and ERK signal pathway inhibitor comprising mogrosides and analogs thereof

Schema-less databases can make data modeling and data management difficult and can detrimentally affect integration with an RDBMS. Inferring a schema from a schema-less database can improve integration by indicating a structure or organization of data in the schema-less database. A schema analyzer can infer a schema by processing data of the schema-less database to identify statistically significant data fields. The schema analyzer then creates a schema that comprises the statistically significant data fields. A data modeler can use the resulting schema along with a schema for a RDBMS to generate a unified data model. A user may submit a query based on the unified data model to obtain results from both databases. The data modeler translates the query from the unified model to be compatible with each of the schemas so that data may be written to or retrieved from each of the schema-less database and the RDBMS.

Unified data model for integration between relational and non-relational databases

Growing community of inventors

Beijing, China

Xiaomeng Zhao