Medtronic Minimed, Inc.

Xiaolong Li

Mike C Liu

Ning Yang

Yuxiang Zhong

Andrea Varsavsky

Bradley Chi Liang

Keith Nogueira

Rajiv Shah

Brian T Kannard

Andy Y Tsai

Taly G Engel

Jaeho Kim

Rebecca K Gottlieb

Pratik J Agrawal

Daniel E Pesantez

Yiwen Li

Barry P Pham

Qingling Yang

Benyamin Grosman

Raghavendhar Gautham

Jeffrey Nishida

Fei Yu

Barry Phong Pham

Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

Glucose sensor system

Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

Sensor systems, devices, and methods for continuous glucose monitoring

Methods and systems for improving the reliability of orthogonally redundant sensors

Embodiments of the invention provide analyte sensors having optimized electrodes and/or configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

Microarray electrodes useful with analyte sensors and methods for making and using them

Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device capable of delivering fluid to a user involves obtaining one or more uncalibrated measurements indicative of the physiological condition, obtaining one or more reference measurements of the physiological condition, determining a raw calibration factor based on a relationship between the one or more uncalibrated measurements and the one or more reference measurements corresponding to the respective uncalibrated measurements of the one or more uncalibrated measurements, and determining an adjusted calibration factor based at least in part on an expected calibration factor and the raw calibration factor, wherein operation of the infusion device to deliver the fluid is influenced by the adjusted calibration factor.

Calibration factor adjustments for infusion devices and related methods and systems

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Porter Ranch, CA, United States of America

Xiaolong Li