Shaanxi University of Science and Technology

Shaanxi Panlong Pharmaceutical Co., Ltd.

Shaanxi Panlong Pharmaceutical Group Limited by Share Ltd.

Xixian New District Fenghou Original Pharmaceutical Technology Co., Ltd.

Xiaolin Xie

Dezhu Zhang

Chengyuan Liang

Lei Tian

Jingyi Li

Liang Xin

Shunjun Ding

Xuhua Zhou

Zhao Ma

Kangxiong Wu

Xuechuan Wang

Shaojun Zhang

Han Li

Xingke Ju

Juan Xia

Jianguo Meng

Zhong Meng

Dan Yang

Yu Wang

Juan Li

Nan Hui

Yuzhi Liu

Danni Tian

Taotao Qiang

Minyi Jia

Nan Qin

Xiuding Yang

Zhenfeng Shi

Yuting Liu

Qingbo Zhao

Min Li

Catherine J Lee

Maggie Lewis

Sundian Liu

Qianqian Zhao

Wenbo Yao

Yanjun Li

Qiao Zeng

Ruina Bian

Chunyang Shi

Weihui Ju

Jialin Li

Boyang Li

Shujun Ding

Jiayun Zhang

The present invention relates to the technical field of medicinal chemistry, and particularly to a method for preparing a 3-tetrazolylmethyl-1,3,5-triazin-2,4-dione compound inhibiting coronavirus 3CL protease activity and use thereof. Specifically, a compound of Formula I, or a pharmaceutically acceptable salt, or an optical isomer, or an isotope-substituted form thereof is provided. The compound effectively inhibits the SARS-CoV-2 3CLactivity, and is useful in the preparation of a SARS-CoV-2 3CLinhibitor to block the replication and transcription of SARS-CoV-2 viruses in patients. The compound prepared in the present invention has high in-vitro safety, and very good prospect of application in the preparation of SARS-CoV-2 3CLinhibitors and anti-SARS-CoV-2 drugs.

3-tetrazolylmethyl-1,3,5-triazin-2,4-dione compound inhibiting coronavirus 3CL protease activity and preparation method and use thereof

A method of preparing a Polygoni Milletii Rhizome tincture includes: preparing a first mixture; extracting the first mixture with 70-90% ethanol under reflux condition to obtain a first extract solution; preparing a second mixture; extracting the second mixture with 50-70% ethanol to obtain a second extract solution; and mixing the first extract solution with the second extract solution to obtain the polygoni milletii rhizome tincture. A method of preparing a Polygoni Milletii Rhizome poultice includes: reparing a Polygoni Milletii Rhizome mixture; mixing the Polygoni Milletii Rhizome mixture and a skin penetration enhancer in water; mixing a moisturizing agent and a binder in water; adding a thickener in water; mixing methylparaben and ethylparaben in 90% ethanol; mixing all solutions to form a mixture; and applying the mixture on a non-woven fabric cloth and drying to form the Polygoni Milletii Rhizome poultice.

Polygoni Milletii Rhizome compositions and methods of preparing the same

Aseed extract includes the following components by weight based on a total weight of theseed extract: 0.4944-0.7142 mg/g of echinacoside, 6.624-7.617 mg/g of oleuropein, 0.4276-0.6309 mg/g of verbascoside, 3.927-4.684 mg/g of syringin, and 4.505-5.250 mg/g of forsythiaside B. A method of preparing theseed extract is disclosed. A composition for treating antibiotic-resistant infections that includes theseed extract is also disclosed.

seed extract composition and its application in antibiotic-resistant infections

Disclosed is a compound of formula I, a pharmaceutically acceptable salt, or a tautomer thereof. formula I. R, R, Rand Rare independently selected from the group consisting of hydrogen, methyl group, tert-butyl group, methoxy group, difluoromethyl, trifluoromethyl, trifluoromethoxy, nitro, halogen, phenyl and aromatic heterocyclic; Ris a hydrogen or halogen; and Ris hydrogen, C1-4 alkane or C1-4 cycloalkane.

3-triazolyl methyl-1,3,5-triazine-2,4-dione compounds and preparation method and application thereof

A compound of formula I or formula II, a pharmaceutically acceptable salt, or a tautomer thereof is disclosed. The Linker is or and n is 1-6.

Protacs targeting coronavirus 3CL protease and preparation method and application thereof

A compound of formula I or formula II, a pharmaceutically acceptable salt, or a tautomer thereof is disclosed. In formula I and II, n is 1-6.

Protacs based on VHL ligand targeting coronavirus 3CL protease and preparation method and application thereof

A method for extracting herbal medicine includes: step one, spray extraction; step two, pressure filtration and concentration; step three, spray and countercurrent precipitation; and step four, concentrating reduced pressure and drying.

Method for extracting herbal medicine

A compound of Formula I: is disclosed. A method of preparing the compound of Formula I is also disclosed. R is alkyl, haloalkyl, aryl, or substituted aryl. Preferably, R is &#x2014;CH, &#x2014;CHCH, &#x2014;CHCHCH, &#x2014;CH(CH), &#x2014;CHCHCHCH, &#x2014;CF, &#x2014;CHF, &#x2014;CHCF, 

Gossypol isocyanate ester compounds with antileukemic activities and a method of preparing the same

A gossypol isatin Schiff base compound with antitumor activities represented by formula I: Rand Rare independently hydrogen, alkyl, cycloalkyl, alkoxy, nitro, halogen, unsubstituted or substituted phenyl, or unsubstituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.

Gossypol isatin schiff base compounds with antitumor activities and a method of preparing the same

A gossypol 7-N-isatin Schiff base compounds compound with antitumor activities represented by formula I: is disclosed. In formula I, R is hydrogen, alkyl, cycloalkyl, alkoxy, unsubstituted or substituted phenyl, or substituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.

Gossypol 7-N-isatin Schiff base compounds with antitumor activities and a method of preparing the same

A gossypol eflornithine Schiff base compound having the following Formula I: is disclosed. A method of preparing the compound of Formula I is also disclosed.

Gossypol eflornithine Schiff base compound with antitumor activities and a method of preparing the same

A compound with antitumor activities is represented by formula I: A method of preparing the compound of formula I is also disclosed.

Gossypol l-arginine schiff base compound with antitumor activities and a method of preparing the same

A compound with antitumor activities is represented by formula A or formula B R, R, R, and Rare independently hydrogen, hydroxyl, alkoxy, halogen, formyl, unsubstituted or substituted alkyl, or unsubstituted or substituted cycloalkyl.

Coumarin-gossypol derivatives with antitumor activities and a method of preparing the same

A compound with antitumor activities represented by formula I: In formula I, Ris alkyl, alkoxy, or ethenyl; and Ris alkyl, alkoxy, or halogen.

Edaravone-gossypol derivatives with antitumor activities and a method of preparing the same

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Xi'an, China

Xiaolin Xie