University of California

Shanghai Meiyue Biotech Development Co., Ltd.

Xiaolin Wang

Abraham Phillip Lee

Steven C George

Christopher C W Hughes

Duc Phan

Yan Feng

Chaodong Wang

Shanghai Yu

Qian He

Zhilong Hu

Yawen Ding

Tao Yue

Feihong Dai

Da Zhao

Shiqiang Li

Christopher C Hughes

A pressure regulator module for a chip-based microfluidic platform is provided. The module includes a microfluidic channel for passing flowable material from the inlet region through the outlet region and into a downstream compartment; one or more microvalves fluidly connected to the microfluidic channel and upstream of the outlet region; and one or more reservoirs fluidly connected to the microvalves, for receiving flowable material diverted by the microvalves, where a flow of flowable material passing from the inlet region toward the downstream compartment is at least partially diverted by the microvalves into the reservoirs as a result of a pressure increase in the microfluidic channel. In some versions, the microvalves are capillary burst valves. A microfluidic chip containing the module and a method of using the module are provided.

Microfluidic pressure regulator for robust hydrogel loading without bursting

A multi-layered microfluidic system featuring tissue chambers for cells in a first layer and a plurality of medium channels for culture medium in a second layer. The tissue chambers fluidly connect to the medium channels such that media flows from the medium channels to the tissue chambers, forming large-scale perfused capillary networks. The capillary networks can undergo angiogenesis and vertical anastomosis. The multi-layered configuration of the system of the present invention allows for flexibility in design.

Multi-layered microfluidic systems for in vitro large-scale perfused capillary networks

A quaternary lactam compound of formula (I). The compound is used in the manufacture of a medicament for the treatment and/or prevention of thrombotic or thromboembolic disorders. 

Quaternary lactam compound and pharmaceutical use thereof

Growing community of inventors

Shanghai, China

Xiaolin Wang