Shanghai Techwell Biopharmaceutical Co., Ltd.

Schneider Electric Industries Sas

Xiaoliang Gao

Jing Xu

Xiaoming Ji

Zhonghao Zhuo

Yi Chen

Shidong Liu

Zhijun Tang

Zhaoli Zhang

Yan Li

Jun Zhu

Haibo Zhang

Bingming He

Xuefeng Ji

Yunman Zheng

Tianhui Xu

Mingquan Mei

Yong Yao

Ming Li

Yangyang Zhuang

A purification method of the compound represented by formula 1 is provided, which includes the following steps: (1) loading crude compound 1 on macroporous adsorbent resin, (2) washing the macroporous adsorbent resin with an aqueous solution, an organic solvent or a mixture solution of organic solvent and water, (3) eluting with an aqueous solution, an organic solvent or a mixture solution of organic solvent and water. The purified compound represented by formula 1 is obtained. 

Purification method of azacyclohexapeptide or its salt

The present invention discloses a crystal of a peptide substance and the preparation method as well as the use thereof. Said crystal B possesses peaks at the following 2&#x3b8; angles in the X-ray diffraction pattern (XRPD): 3.2&#xb1;0.2&#xb0;, 5.4&#xb1;0.2&#xb0;, 6.2&#xb1;0.2&#xb0;, and 9.3&#xb1;0.2&#xb0;.

Crystal of peptide substance as well as the preparation method and use thereof

The crystalline form A of Bimatoprost of formula I, its preparation method and use are provided. There are characteristic peaks where diffraction angles 2&#x3b8; are 3.2&#xb1;0.2&#xb0;, 5.5&#xb1;0.2&#xb0;, 11.4&#xb1;0.2&#xb0;, 16.7&#xb1;0.2&#xb0;, 17.6&#xb1;0.2&#xb0;, 19.9&#xb1;0.2&#xb0;, 20.8&#xb1;02&#xb0; and 22.8&#xb1;0.2&#xb0; in the X-ray powder diffraction pattern of the crystalline form A.

Crystalline form of Bimatoprost, preparation method and use thereof

High yield antibiotics producing fungus strain, preparation method and use thereof are provided. The fungus strain is a mutant derived from, and deposited in CGMCC with the accession number of CGMCC 2933. The preparation method concludes following steps: (a) mixing the culture media ofstrain ATCC 20957 with nitrosoguanidine, and obtaining mixture a; (b) mixing lywallzyme with the mixture a, and obtaining protoplasts; (c) regenerating the protoplasts, and obtaining single clones; and (d) culturing the single clones, then obtaining the mutant strain. This fungus strain has stable genetic and producing property, produces little impurities in fermentation, and is suitable to be used in industry.

[object Object]

The invention provides a novel microorganism producing pravastatin sodium, as well as the method for producing pravastatin sodium by using this microorganism.CGMCC 0624 of the invention is highly tolerant to mevastatin sodium, and has a high transformation rate of mevastatin sodium, and can produce pravastatin sodium with a high efficiency and low cost.

Microorganism and the process for preparation of pravastatin sodium

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Shanghai, China

Xiaoliang Gao