Agilent Technologies, Inc.

Xiaoli Wang

Ta-Chen Wei

Wu Chen

Yingyu Li

Modified silica particles are provided. Aspects of the particles include an outer layer that is composed of organically-modified silica comprising a siloxane-linked hydrophilic group, such as a charged functional group or a polar neutral functional group. The modified silica particles can form the basis of a variety of chromatography support materials. Also provided are methods of preparing the subject particles. Aspects of the methods include contacting silica particles with water, an ionic fluoride and an organosilane reagent comprising a hydrophilic moiety to produce modified silica particles wherein the hydrophilic moiety of the organosilane reagent is incorporated into an outer layer of the silica particles. Chromatography supports and kits including the subject particles and methods of using the same are also provided.

Functionalized particles having modified phases

Superficially porous particles are provided. Aspects of the superficially porous particles include a non-porous inner core and a porous outer shell that includes inner and outer porous regions. The inner porous region can include ordered cylindrical pores substantially perpendicular to the non-porous inner core. The outer porous region can include conical pores which extend to the surface of the particles and which are in fluid communication with the cylindrical pores of the inner porous region. Also provided are methods of making the subject superficially porous particles. Aspects of the methods include subjecting substantially solid inorganic oxide particles to agitation in an aqueous solution in the presence of a first cationic surfactant and a second anionic surfactant, which together form micelles, to pseudomorphically transform the particles.

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West Chester, PA, United States of America

Xiaoli Wang