Xdcexplorer (shanghai) Co., Ltd.

Jiangsu Hyamab Pharmaceutical Co., Ltd.

Xiaolan Sun

Lile Liu

Ying Zhang

Qing Duan

Tatchi Teddy Yang

Shaoping Hu

Xinxiu Yang

Shiyong Gong

Hongzhuan Gu

Zhengrong Shuai

Haishan Luo

Hu Liu

Fei Peng

Tengjiao Xu

Yuzhu Chen

The present invention provides a humanized anti-TPBG antibody, a preparation method therefor, a conjugate thereof, and applications. The humanized anti-TPBG antibody comprises: (a), a framework region comprising a residue of a human antibody framework region; and (b) one or more CDRs of a light-chain variable region as shown in the SEQ ID NO:4 or 8 or one or more CDRs of a heavy-chain variable region as shown in the SEQ ID NO:2 or 6.

Humanized anti-TPBG antibody, preparation method therefor, conjugate thereof, and applications

Provided herein are anti-PD-L1 antibodies and antigen-binding fragments thereof. Also provided are nucleic acids encoding the antibodies, compositions containing the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancer, infectious diseases and autoimmune diseases.

Anti-PD-L1 antibodies and uses thereof

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Shanghai, China

Xiaolan Sun