Dalian University of Technology

Dalian Chromas Bioscience Co., Ltd.

Zhuhai Ninestar Management Co., Ltd.

Other

Shenzhen Mindray Bio-medical Electronics Co., Ltd.

Dalian Firstar Information Materials Co., Ltd.

Ninestar Management Co., Ltd.

Dalian Chromas Biosctence Co., Ltd

Xiaojun Peng

Jiangli Fan

Shiguo Sun

Jingyun Wang

Rong Zhang

Feng Wang

Jinhe Wu

Shaolei Li

Jianzhou Zhang

Fengling Song

Tong Wu

Mingle Li

Jianjun Du

Qichao Yao

Zhigang Yang

Yanxia He

Bing Xu

Tao Liu

Jianhui Shao

Hua Zhang

Zhi Long

Si Zhang

Hao Zhu

Yana Bian

Haidong Li

Saran Long

Shiyu Li

Fanming Meng

Bingshuai Wang

Fan Jiangli

Jingyue Wang

Zhengru Yang

Honglin Li

Licheng Liaoning

Disclosed are an oxazine compound and an application thereof. The oxazine compound has a structure of a general formula F. The oxazine compound described in the disclosure is a photo/acoustic dynamic active organic molecule with near-infrared absorption-emission function as well as photosensitivity and acoustic sensitivity. Maximum absorption and emission wavelengths of the compound are both greater than 660 nanometers, and a triplet-state conversion rate of the compound is high; and under illumination or ultrasound, the compound can produce reactive oxygen species with high efficiency, which has a good killing effect on cancer cells and cancer tissues, and almost has no toxic or side effects on normal tissues while achieving photo/acoustic dynamic therapy on tumors.

Oxazine compound and application thereof

A photosensitizer and derivative, application thereof. The photosensitizer has the structure of general formula I, wherein X is S or Se, Y is organic or inorganic ion, Rand Rare independently selected from H, alkyl, alkoxy, alkyl amido, alkyl azide and the like; Ris selected from H, alkyl, alkoxy, amino sulfonyl, hydroxyl, carboxyl and the like, and Lis a linker selected from &#x2014;(CH)&#x2014; or &#x2014;(CHCHO)&#x2014;. The derivatives are molecular medicines with drug molecules of anticancer and chemotherapy or tumor targeting function connected to the said photosensitizer. The photosensitizer has excellent near infrared characteristics and low dark toxicity and is used in the field of photodynamic tumor therapy. The introduction of benzophenothiazine or benzophenoselenazine into derivatives with tumor-targeting function could improve the specific uptake of photosensitizer in tumor tissues. Moreover, clinical anticancer drugs can be introduced into the structure of benzophenothiazine or benzophenoselenazine to achieve the purpose of combining therapy of photodynamic therapy and chemotherapy. 

Photosensitizer and derivatives and application thereof

The present invention provides a category of cyano-substituted asymmetric cyanine dyes having the following general structural Formula I and its synthesizing method. The cyano-substituted asymmetric cyanine dyes in present invention are easily synthesized and have long emission wavelength, high molar extinction coefficient, high sensitivity, good light stability, high fluorescence quantum yield after binding with nucleic acid, and low cell toxicity, which is beneficial for application as fluorescent dyes and could also be used in the field of identifying nucleic acid molecules, clinical diagnostics, and immunoassay testing etc. 

Class of cyano-substituted asymmetric cyanine dyes, synthesizing method and application thereof

The present invention provides a difluoroboron dipyrromethene fluorescent probe having a structure represented by the following general formula I, and a production method and an application thereof. Said difluoroboron dipyrromethene fluorescent probe exhibits low background fluorescence, and a rapid and significant fluorescence enhancement up to 100 times after the addition of hypochloric acid. The fluorescent intensity of said fluorescent probe shows a good linear relation with the concentration of hypochloric acid in a nanomole level, and the detection limit thereof is 0.56 nanomole. Said fluorescent probe has good selectivity since it hardly responds to other reactive oxygen species such as HO, O, TBHP, HO., TBO.,Oand NO., and is not interfered by pH in a wide range. Said fluorescent probe can be applied to detect hypochloric acid in living cells. 

Difluoroboron dipyrromethene fluorescent probe, production method and application thereof

The present invention provides a novel category of naphthalene-based two-photon fluorescent probes having a general formula I, wherein: X is selected from the X, X, Xand X; The mentioned two-photon fluorescent probes have a low fluorescence background in the non-tumor cells and tissues, and have a strong and specific fluorescent signal in the tumor cells and tissues. These probes have a certain level of water-solubility, while having good membrane permeability. In addition, they have a bigger effective two-photon absorption cross section. The compounds of the present invention also have a lower biotoxicity, phototoxicity and photobleaching. There is sufficient difference between the spectral range thereof and that of a biological sample. 

Naphthalene-based two-photon fluorescent probes, preparation method and use thereof

The present invention relates to a class of magenta dyes, their preparation methods and applications. The magenta dyes include the compounds which simultaneously contain carboxyl group, sulfonic acid group and the carbonyl propyl sulfurylsulfonic acid on the anthrapyridone skeleton, showing in the form of general formula (I) or their mixtures. In the general formula (I): A may be cation M, or substituted or unsubstituted benzyl group, or substituted or unsubstituted naphthyl methyl; M, M, Mare respectively cation or cationic groups; Sulfonic acid group (SOM)may located any position of the benzene ring, of which m is an integer of 0-2. As containing carboxyl (or carboxylic benzyl ester or naphthoate), sulfonic acid groups and carbonyl propyl sulfuryl simultaneously, the magenta dyes of the present invention feature outstanding tone, brightness, light resistance, water resistance, ozone resistance as well as solubility and solution stability, etc. 

Magenta dyes and their preparation methods and applications

The present invention relates to a class of compounds of general formula (I) or their salts of general formula (II): In formula (I)-(II), the substituents (A)p and (SOH)n on the benzene ring are at the ortho, meta or para position, n is 0-2, and p is 0-3; M is selected from Li, Na, K, NHor organic ammonium salt NRRRR, where R, R, R, Rare the same or different H, Calkyl groups, cyclohexyl groups, CHCHOH, CH(CH)CHOH or benzyl groups; where p&#x3e;0, A stands for the same or different groups selected from: H, CN, NO, NH, F, Cl, Br, Calkyl group, cyclohexyl group, phenyl group, benzyl group, phenoxy group, Calkoxy group, Calkylthio group, SOCH&#x2550;CH, SOCHCHA, NRCORor NRSOR.

Anthrapyridone sulfonic acid compounds and their preparation methods and applications

The present invention discloses a fluorescent probe compound which solved the problem of fluorescence quenching by Pd, and its preparation method and use as well. Excitation and emission wavelengths of the probe compound are in visible light region. The probe compound is highly sensitive and displays good selectivity for Pdin near-neutral pH range. In detection of Pdin 0-10 ppb level, fluorescence is evidently enhanced, and Pdin the level as low as 5 nM can be detected. Fluorescence intensity is well linearly correlated to Pdconcentration. The probe compound can be used for detection of contaminating palladium and residual palladium in drug, soil, water sample and reactor.

Fluorescent probe compounds, preparation method and application thereof

A pentamethine cyanine fluorescent dye having the general formula I, a synthetic method and a use thereof are disclosed. In the general formula, X is CHO or CHCRR; Rand Rare independently selected from the group consisting of (CH)Rand et al.; Rand Rare independently selected from the group consisting of CN, COOH and COOR; R, Rand Rare independently selected from the group consisting of H, SORand COOR; Ris H or Calkyl; Ris H or CH; Ris N(RRRR); Ris Calkyl; R, R, R, Rand Rare independently selected from the group consisting of H, Calkyl, (CH)ORand (CHRCHO)R; Yis halogen anion or OTs; and n, m and p are integers of 0-18. The dye can be utilized to sensitively detect viscosity of micro-environment such as tissues and cells. 

Pentamethine cyanine fluorescent dyes, preparation methods and uses thereof

The present invention relates to compounds shown in the general formula (I) or (III), the salts thereof or their mixtures, as well as their preparation method and application. In the general formula (I), Xis H or COH; Xis OH or phenyl group with 0-2 sulfonic acid substituents, and the sulfonic acid substituents are located at random positions of a benzene ring; when Xis OH, Xis H; when Xis phenyl group with 0-2 sulfonic acid substituents, Xis H or COH; n is an integer of 0-2; and in the general formula (III), n and m are respectively an integer of 0-2. The compounds and the mixtures not only have improved light resistance, ozone resistance and water resistance, but also have excellent water solubility and long-term stability in ink-jet ink. 

Carbonyl propyl sulfuryl anthrapyridone sulfonic acid compounds and their preparation methods and applications

A pentamethine cyanine fluorescent dye with N-substituting at &#x3b2;-position of conjugated chain is disclosed. The dye reacts with biosubstrate including protein, liposome and DNA, and shows excellent selectivity. It has good living cell membrane permeability and shows good selectivity in living cell staining In addition, the dye has good stability and low background fluorescence, and can be used together with other fluorescent dyes having consistent wavelengths for single-channel excitation and multi-channel detection. The dye can be used in the fields of protein labeling and detecting, fluorescence immunoassay and living cell selective imaging and the like.

Pentamethine cyanine fluorescent dye with N-substituting at &#x3b2;-position of conjugated chain

The disclosure provides fluorescence probe compounds of formula I, their preparation methods and applications. These compounds are useful in detecting mercury ions.

Fluorescent probe compounds, preparation method and use thereof

The invention is related to a weather-resistant dye and use thereof, which contains in molecules thereof not only chromophoric parent D, but also electron-accepting group Q which is linked with dye parent D through non-conjugated carbon link L to constitute D-L-Q dye molecule; the electron-accepting group Q has such a HOMO energy level that is lower than the HOMO energy level of the dye chromophoric parent D. The dye has sun-resistance and anti-ozone performances, which can be used as colorant in the ink, dope, lacquer, toner powder for laser printing, marker, paper, fabric, glass, porcelain or polymer.

Weather-resistant dye and use thereof

The present invention provides a category of cyanine dyes having the following general structural Formula I, wherein X is defined as C(CH), O, S or Se; m is an integer from 1 to 18, Rand Rare each independently chosen from H, Calkyl, OR, Calkyl-ORor halogen; Ris pyrrolyl, imidazolyl, piperidinyl, piperazinyl, morpholinyl, guanidino, NHRor N(R); Ris Calkyl, benzyl or (CH)R; Ris saturated and/or unsaturated, straight-chained and/or branched-chained Calkyl, hydroxy alkyl, mercapto-alkyl, amino alkyl, acyl, phenyl, naphthyl or benzyl; Ris a Calkyl; Ris H or a Calkyl; Yis an anion. The mentioned compounds can be applied to staining biological samples, to the fields of nucleic acids labeling, blood cell analysis, clinical diagnosis, immunological assays and etc. 

Fluorescent dyes, methods of synthesis and applications thereof

The present disclosure provides the asymmetric cyanine fluorescent dyes of formula I in which X, n, R, R, R, R, Rand Yare as defined in the specification. The present disclosure also provides conjugates of the fluorescent dyes, methods for preparation thereof, compositions comprising the fluorescent dyes, and methods for staining biological samples using the fluorescent dyes and compositions thereof. 

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Dalian, China

Xiaojun Peng