Roche Molecular Systems, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-La Roche Ag

Xiaoju Max Ma

Chitra Manohar

Ann Begovich

Ellen C Ordinario

Dwight Kuo

Cindy Cheung

Grantland Hillman

Alison Tsan

Rajiv Dua

Lily Wong

Huan Truong

Javelin Chi

Michael Lee

Jaya Rajamani

Provided herein are methods and compositions to detect MET exon 14 skipping using RT-PCR, and methods of treating individuals with MET exon 14 deleted cancers.

Detection of MET exon 14 deletions and associated therapies

Provided herein are methods and compositions for multiplex detection of a large number of actionable gene fusions with very high sensitivity and specificity. The present methods and compositions can detect ALK, RET, and ROS1 gene fusions, optionally in combination with other mutations and fusions.

Multiplex PCR detection of ALK, RET, and ROS fusions

The invention comprises reagents and methods for detecting cancer-associated mutations in the human EZH2 gene. Further, a method of detecting the mutations and a method of treatment are disclosed.

Methods and compositions for detecting mutation in the human EZH2 gene

Provided herein are methods and compositions for detecting gene fusions, e.g., relevant to cancer. The present methods and compositions can be used to detect gene fusions with very high sensitivity and specificity. The present methods and compositions can detect gene fusions, e.g., in free circulating tumor RNA from a plasma sample.

Multiplex PCR to detect gene fusions

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San Carlos, CA, United States of America

Xiaoju Max Ma