Allergan, Inc.

Allergan Industrie, Sas

Viacyte, Inc.

Novocell, Inc.

Xiaojie Yu

Nicholas J Manesis

Futian Liu

Athene Wan Chie Chan

Jacob Pollock

Gabriel N Njikang

Darin J Messina

Cunqi Cui

Elizabeta Pavlovic

Dennis E Van Epps

Sumit Paliwal

Lauren Elizabeth Kokai

Hengli Liu

Athene W Chan

Jessamine P Winer-Jones

Kevin Allen D'Amour

Chad Green

Alan D Agulnick

Allan J Robins

Thomas C Schulz

Olivia Kelly

Anne Bang

Monica A Serban

E Edward Baetge

Kate M Smither

Eugene Brandon

Athene Wan Chan

Jeffrey Alan Hubbell

Lance Steward

Patrick Michael Hughes

Emmanuel Edward Baetge

Guang Wei Lu

Paul Latta

Sheshadri Neervannan

David Scharp

Chengyun Yue

Eugene P Brandon

Kevin A D'amour

Jacob F Pollock

Iossif A Strehin

Jessamine P Winer

Ed Baetge

Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a collagen component.

Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation

Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

Hyaluronic acid-collagen matrices for dermal filling and volumizing applications

The present specification discloses porogen compositions comprising a core material and shell material, methods of making such porogen compositions, methods of forming such porous materials using such porogen compositions, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.

Porogen compositions, methods of making and uses

The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions made with a di-amine or multiamine crosslinker in the presence of a carbodiimide coupling agent.

Dermal filler compositions

Microneedle arrays for introducing an active ingredient through a skin surface of a subject can include a base layer, a plurality of microneedles projecting from the base layer, and an active ingredient. Each of the microneedles comprises an elongate body having a proximal portion and a distal portion, in which the proximal portion is attached to the base layer. Each of the microneedles comprises at least one dissolvable polymer. The active ingredient is incorporated in the elongate body, and the active ingredient is present only in the distal portion and at least internally in the distal portion.

Microneedle array with active ingredient

Provided are injectable, hyaluronic acid-based dermal filler compositions including conjugated vitamin C derivatives. The compositions provide for extended release of active vitamin C into tissue, promoting collagenesis and other benefits to skin.

Dermal filler compositions including antioxidants

The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions which are particularly advantageous for correction of fine lines in the face.

Dermal filler compositions for fine line treatment

Compositions useful as dermal fillers and methods using such compositions to treat various skin and soft tissue conditions. The dermal fillers can comprise silk attached to hyaluronic acid using for example two cross linkers and can be used to treat of facial imperfections, facial defects, facial augmentations, breast imperfections, breast augmentations or breast reconstructions.

Cross linked silk-hyaluronic acid composition

Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a silk fibroin component.

Co-crosslinked hyaluronic acid-silk fibroin hydrogels for improving tissue graft viability and for soft tissue augmentation

Provided are injectable, hyaluronic acid-based hydrogel compositions including conjugated vitamins.

Growing community of inventors

Irvine, CA, United States of America

Xiaojie Yu