Northwest University

Hong-taoism Research Institute of Analytical Science and Technology Ltd., Shaanxi Province

Xiaohui Zheng

Yajun Bai

Fanggang Qin

Pei Liu

Shixiang Wang

Xirui He

Yanrui Ding

Yujie Cai

Yi Yan

Pu Jia

Yajun Zhang

Sha Liao

Xiaoxiao Wang

Jiacheng Fang

Yi Zhang

Qunzheng Zhang

Xinfeng Zhao

The disclosure discloses a strain and method for producing rosmarinic acid, and belongs to the technical field of bioengineering. The disclosure constructs a recombinant cell or a combination of recombinant cells expressing 4-coumarate: CoA ligase, rosmarinic acid synthase, polyphosphate kinase 2-I (PPK2-I) and polyphosphate kinase 2-II (PPK2-II), and utilizes the recombinant cell or the combination of recombinant cells to catalyze Danshensu and caffeic acid for synthesizing rosmarinic acid. The disclosure has good industrial application prospects.

Strain and method for producing rosmarinic acid

Provided are a tripeptide compound, a preparation method therefor, and an application thereof. The structure of the related compound is represented by formula (I). The provided compound has angiotensin converting enzyme inhibiting bioactivity, and the compound and a pharmaceutical composition thereof play a role in preventing and treating hypertension and other cardiocerebral vascular system diseases.

Tripeptide compound, preparation method therefor, and application thereof

Use of isopropyl &#x3b2;-(3,4-dihydroxyphenyl)-&#x3b1;-hydroxypropionate (IDHP) in the preparation of a drug or a health product for prevention and treatment of coronary atherosclerosis diseases. The IDHP can also be used to inhibit platelet aggregation, to promote angiogenesis, and to prepare a drug and a health product for prevention and treatment of senile vascular dementia.

Use of IDHP in preparation of drug or health product for prevention and treatment of coronary atherosclerosis disease

The present invention relates to &#x3b1;-asary-laldehyde ester. The chemical structure of the related &#x3b1;-asary-laldehyde ester is of formula I.

&#x3b1;-Asary-laldehyde ester, preparation method therefor, and application thereof

The present invention relates to a compound of the formula (I), wherein R, Rand Rare each independently selected from H, OH, F, Cl, Br, methoxy and ethoxy; or alternatively, Rand Rtogether form &#x2014;OCHO&#x2014;, Ris selected from H, OH, methoxy, ethoxy and halogens; Ris OH or acyloxy; Ris cycloalkoxyl, amino and substituted amino, and when Ris selected from amino, at least one of R, Rand Ris not H. The present invention further relates to a process for synthesizing a compound of the formula (I), and use of the compound of the formula (I) in the manufacture of a medicament for the prevention or treatment of cardiovascular or cerebrovascular diseases. 

Substituted &#x3b2;-phenyl-&#x3b1;-hydroxy-propanoic acid, synthesis method and use thereof

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Shaanxi, China

Xiaohui Zheng