Global Life Sciences Solutions USA LLC

General Electric Company

Ge Avio S.r.l.

Xiaohua Zhang

Weston Blaine Griffin

Reginald Donovan Smith

Brian Michael Davis

Vandana Keskar

Alex David Corwin

Kashan Ali Shaikh

Chengkun Zhang

Zhen Liu

Bugra Han Ertas

Flavia Turi

Arthur William Sibbach

Andrea Piazza

Kenneth Roger Conway

Miriam Manzoni

Brandon Wayne Miller

Minfeng Xu

Walter John Smith

Ye Bai

Susumu Mine

Evelina Roxana Loghin

A gearbox assembly includes a gearbox and a gutter for collecting a gearbox lubricant scavenge flow from the gearbox. The gutter is characterized by a lubricant extraction volume ratio between 0.01 and 0.3, inclusive of the endpoints. The lubricant extraction volume ratio is defined by Vis a gutter volume of the gutter and Vis a gearbox volume of the gearbox. A gas turbine engine includes the gearbox assembly and a lubrication system. The lubrication system includes a tank that stores a lubricant therein, one or more lubricant pumps for generating a flow of lubricant from the tank to the gearbox assembly, and a flow rate control valve. The flow rate control valve has a flow inlet and a flow outlet and defines a variable throughput from the flow inlet to the flow outlet for controlling a flowrate of the lubricant to the gearbox assembly.

Gearbox assembly with lubricant extraction volume ratio

A gearbox assembly includes a gearbox and a gutter for collecting a gearbox lubricant scavenge flow from the gearbox. The gutter is characterized by a lubricant extraction volume ratio between 0.01 and 0.3, and given by Vis a gutter volume of the gutter and Vis a gearbox volume. A gas turbine engine includes a combustion section and the gearbox assembly. A fuel delivery system includes a fuel supply line for delivering fuel to the combustion section. A lubrication system includes a lubricant supply line for delivering lubricant to the gearbox assembly. A thermal management system includes a fuel-lubricant heat exchanger for cooling the lubricant with the fuel. The thermal management system selectively directs the fuel through fuel bypass lines or the lubricant through lubricant bypass lines to bypass the fuel-lubricant heat exchanger based on a fuel temperature or a lubricant temperature.

In an embodiment, a tubing module for a bioprocessing system includes a first tubing holder block configured to receive at least one pump tube and hold the at least one pump tube in position for selective engagement with a peristaltic pump, a second tubing holder block configured to receive a plurality of pinch valve tubes and hold each pinch valve tube of the plurality of pinch valve tubes in position for selective engagement with a respective actuator of a pinch valve array, and wherein the first tubing holder block and the second tubing holder block are interconnected.

Apparatus for fluid line management in a bioprocessing system

A gas turbine engine includes a gearbox assembly that includes a gearbox and a gutter for collecting a gearbox lubricant scavenge flow from the gearbox. The gutter is characterized by a lubricant extraction volume ratio between 0.01 and 0.3, inclusive of the endpoints. The lubricant extraction volume ratio defined by: is a gutter volume of the gutter and Vis a gearbox volume. The gas turbine engine includes a lubricant flow control system that includes a variable flow lubricant pump that generates a pump variable flow of lubricant to the gearbox assembly. The gearbox assembly has a variable consumption demand for delivery of lubricant. A lubricant flow controller is configured to generate a pump control command for the variable flow lubricant pump to produce the pump variable flow of lubricant based on the variable consumption demand.

A gearbox assembly includes a gearbox having a gear assembly and a gutter for collecting a gearbox lubricant scavenge flow from the gearbox. The gutter is characterized by a lubricant extraction volume ratio between 0.01 and 0.3, inclusive of the endpoints. The lubricant extraction volume ratio is defined by is a gutter volume of the gutter and Vis a gearbox volume. A gas turbine engine includes the gearbox assembly and a lubrication system. The lubrication system includes a sump that is a primary reservoir having a first lubricant level and a secondary reservoir in the gearbox assembly. The secondary reservoir has a second lubricant level. The lubrication system fills the secondary reservoir with a lubricant between the first lubricant level and the second lubricant level. The gear assembly collects the lubricant in the secondary reservoir to supply the lubricant to the gear assembly.

A bioprocessing system includes a first fluid assembly having a first fluid assembly line connected to a first port of a first bioreactor vessel though a first bioreactor line of a first bioreactor vessel, a second fluid assembly having a second fluid assembly line connected to a second port of the first bioreactor vessel through a second bioreactor line of the first bioreactor vessel, and an interconnect line providing for fluid communication between the first fluid assembly and the second fluid assembly, and for fluid communication between the second bioreactor line of the first bioreactor vessel and the first bioreactor line of the first bioreactor vessel.

System and method for fluid flow management in a bioprocessing system

An apparatus for bioprocessing includes a housing, a drawer receivable within the housing, the drawer including a plurality of sidewalls and a bottom defining a processing chamber, and a generally open top, the drawer being movable between a closed position in which the drawer is received within the housing, and an open position in which the drawer extends from the housing enabling access to the processing chamber through the open top, and at least one bed plate positioned within the processing chamber and configured to receive a bioreactor vessel.

Bioprocessing apparatus

A bioprocessing system includes a first module configured for enriching and isolating a population of cells, a second module configured for activating, genetically modifying, and expanding the population of cells, and a third module configured for harvesting the expanded population of cells.

Systems and methods for bioprocessing

A gearbox including a gear and a gutter. The gear is rotatable about a rotational axis in a rotational direction. The gear has a radial direction and an axial direction, and the gear expels oil radially outward when the gear rotates. The gutter is positioned radially outward of the gear in the radial direction of the gear to collect oil expelled by the gear when the gear rotates. The gutter includes an axial surface, a plurality of radial surfaces including a first radial surface and a second radial surface, and at least one opening to allow the oil collected in the gutter to flow therethrough. Each of the first radial surface and the second radial surface is oriented in a direction intersecting the axial surface, and the at least one opening is formed on both the axial surface and one of the first radial surface and the second radial surface.

Oil scavenge system for a gearbox

A gearbox for a gas turbine engine. The gearbox including a rotor and a gutter. The oil system is configured to supply oil to the gearbox. The rotor is rotatable about a rotation axis. The rotor expels oil radially outward when the rotor rotates. The gutter is positioned radially outward of the rotor to collect oil expelled by the rotor when the rotor rotates. The gutter is positioned eccentrically with respect to the rotor.

Eccentric gutter for an epicyclical gear train

A bioreactor vessel includes a bottom plate, a vessel body coupled to the bottom plate, the vessel body and the bottom plate defining an interior compartment therebetween, and a plurality of recesses formed in the bottom plate, each recess of the plurality of recesses being configured to receive a corresponding alignment pin on a bed plate for aligning the bioreactor vessel on the bed plate.

Bioprocessing vessel

Provided are techniques that may include a disposable magnetic cell isolation holder having one or more passages that accommodate a magnetic retention material to facilitate magnetic cell isolation without adjustment of magnetic field parameters between isolation procedures using different magnetic particle sizes. When the magnetic cell isolation holder is coupled to a magnetic field generator, a first passage corresponding to a smaller particle size is positioned in a magnetic field where the magnetic field characteristics are different relative to a second passage, of a second holder or in the same holder, for use with another bead size.

Magnetic cell isolation techniques

A method includes introducing a suspension including cells suspended in a cell culture medium through a feed port or a drain port into a cavity of a cell culture vessel, the suspension being in an amount sufficient to cover a gas permeable, liquid impermeable membrane positioned at a bottom of the cell culture vessel, the feed port being disposed through a surface of the cell culture vessel and configured to permit additional cell culture medium into the cavity, and the drain port being disposed through the surface of the cell culture vessel and configured to permit removal of the cells, cell culture medium, and used cell culture medium from the cavity, allowing the cells to settle on the gas permeable, liquid impermeable membrane by gravity, removing the used cell culture medium through the drain port and introducing the additional cell culture medium through the feed port such that a constant volume is maintained in the cell culture vessel until the cells expand to a desired cell density, wherein the removing and introducing are performed subsequent to allowing the cells to settle on the gas permeable, liquid impermeable membrane, resuspending the cells in the cell culture medium in the cell culture vessel, wherein the resuspending is performed after the desired cell density is attained, and removing the resuspended cells and the cell culture medium through the drain port.

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Niskayuna, NY, United States of America

Xiaohua Zhang