Tianjin Institute of Pharmaceutical Research Co., Ltd.

Xiaohua Kong

Wei Liu

Bingni Liu

Yuquan Li

Xuyuan Liu

Naxia Zhao

Qian Shang

Yingmei Han

Guangping Xia

Weiling Kong

Jing Jin

Provided are a polypeptide derivative, modified derivative or salt thereof, and use of the polypeptide derivative, modified derivative or salt thereof, wherein the polypeptide derivative, modified derivative or salt thereof comprises a polypeptide having the sequence of following general formula I, general formula I: wherein the definitions of X, X, X, X, X, X, X, X, X, X, X, X, X, Xand Xare consistent with the definitions in the claims and the description. The polypeptide derivative provided by the invention has a dual agonistic effect on GC/GLP-1 receptors, so that a synergistic effect on energy metabolism is generated, which can effectively reduce blood glucose while reducing body weight and improving the body fat level, and the efficacy is better than that of a single GLP-1 receptor agonist.

Glucagon-derived peptide and use thereof

Growing community of inventors

Tianjin, China

Xiaohua Kong