Bristol-Myers Squibb Pharma Company

Other

Bristol-Myers Squibb Compnay

Dupont Pharmaceuticals Company

Xiaohua He

Carl P Decicco

Chu-Biao Xue

Jingwu Duan

Robert J Cherney

John L Gilmore

James Edward Sheppeck

Xiao-Tao Chen

Ronald L Magolda

Irina Cipora Jacobson

Chu-Bio Xue

Elizabeth Arner

David Nelson

The present invention describes novel 1,3-dihydro-imidazol-2-one or 1,3-dihydro-imidazol-2-thione compounds of formula (I): or a stereoisomer or pharmaceutically acceptable salt or solvate thereof, wherein A, L R, R, Rand Rare defined in the present specification, which are useful as selective inhibitors of MMP, TACE, aggrecanase or a combination thereof. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.

Substituted 1,3-dihydro-imidazol-2-one and 1,3-dihydro-imidazol-2-thione derivatives as inhibitors of matrix metalloproteinases and/or TNF-&#x3b1; converting enzyme (TACE)

The present application describes novel cyclic hydroxamic acids of formula I:or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms selected from O, N, NR, and S(O), and 0-1 carbonyl groups and the other variables are defined in the present specification, which are useful as metalloprotease inhibitors.

Cyclic hydroxamic acid as metalloproteinase inhibitors

1,2,-Disubstituted cyclic inhibitors of matrix metalloproteases and TNF-alpha

Cyclic hydroxamic acids as metalloproteinase inhibitors

This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tissue degradation and inhibitors of the release of tumor necrosis factor. The present invention also relates to pharmaceutical compositions comprising such compounds and to methods of using these compounds for the treatment of inflammatory diseases.

Macrocyclic compounds as metalloprotease inhibitors

Growing community of inventors

Hockessin, DE, United States of America

Xiaohua He